Question · asked by 1 review
Non-syndromic cleft lip and palate (CLP) status and its oral microbiota (exposure/grouping) vs Children and adolescents aged 0-18 years without CLP (controls): Lactobacillus spp. salivary/plaque counts (cariogenic microbiota)
- Population
- Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
- Intervention
- Non-syndromic cleft lip and palate (CLP) status and its oral microbiota (exposure/grouping)
- Comparison
- Children and adolescents aged 0-18 years without CLP (controls)
- Outcome
- Lactobacillus spp. salivary/plaque counts (cariogenic microbiota)
A meta-analysis found no significant difference in mean Lactobacillus spp. levels between children with and without CLP, with high heterogeneity; the evidence is ungraded.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Non-syndromic cleft lip and palate (CLP) status and its oral microbiota (exposure/grouping) vs Children and adolescents aged 0-18 years without CLP (controls) Lactobacillus spp. salivary/plaque counts (cariogenic microbiota) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP) · Multiple countries; pediatric cleft/craniofacial care; saliva, dental plaque, subgingival plaque and nasal/oropharyngeal samples A meta-analysis found no significant difference in mean Lactobacillus spp. levels between children with and without CLP, with high heterogeneity; the evidence is ungraded. Characterization of the oral microbiota and the relationship of the oral microbiota with the dental and… (2024) All outcomes | For the outcome of the presence of Lactobacillus spp., there were no significant differences between patients with CLP and healthy patients, and the diversity of the studies led to high heterogeneity; however, the p… | Not reported | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Characterization of the oral microbiota and the relationship of the oral microbiota with the dental and periodontal status in children and… 2024 All outcomes | Publications from 1 January 1985 to 30 June 2020 (search date not separately reported) | 24 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.