Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) · Adolescents (10-19 years)
Malocclusion (DAI) probably increases the prevalence of impaired OHRQoL (CPQ 11-14) by about 15% in adolescents (RR/PR 1.15, 95% CI 1.12-1.18; moderate certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing pulpotomy
MTA and CEM performed comparably for clinical and radiographic success (2 RCTs, not pooled; ungraded).
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; permanent teeth
Over 1 year in permanent teeth, secondary caries did not differ significantly between RMGIC and GIC (RR 1.82, 95% CI 0.45-7.28; low certainty).
1 finding from 1 review
Oral health-related quality of life · Indian children, adolescents and adults
One GOHAI study found no significant difference in OHRQoL by malocclusion status; ungraded.
2 findings from 1 review
Malocclusion and QoL (continuous, GOHAI): no significant difference in OHRQoL between individuals with and without malocclusion (Appukuttan 2016). Single study, not pooled.
1 study
GRADE not reported
OR 5.44 [1.61, 18.39]
6 studies · 3720 participants
Very low
Oral health-related quality of life · Indian children and adults
Two studies found bruxers have poorer OHRQoL than non-bruxers; narrative, ungraded.
1 finding from 1 review
Bruxism and QoL (continuous, OHIP-14): bruxers have poorer OHRQoL than non-bruxers (Thetakala 2018, Suguna 2020). Two studies, 284 individuals; not pooled.
2 studies · 284 participants
GRADE not reported
Cariogenic bacteria (Mutans streptococci) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Chlorhexidine mouthwash reduced Mutans streptococci versus blank control, but certainty is very low.
1 finding from 1 review
New coronal caries in permanent first molars (caries prevention) · Children with dental caries in permanent (first) molars
ART within a brushing programme significantly reduced caries vs control (p<0.01; ungraded).
1 finding from 1 review
Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment
It is very uncertain whether part-time clear plastic (removable) retainer changes stability: Little's Irregularity Index (lower arch) compared with any type of fixed (bonded) retainer (very low certainty).
1 finding from 1 review
MMP-2 presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
MMP-2 may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-2 may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain.
7 studies · 373 participants
Very low
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported that toothache has a high impact on oral health-related quality of life.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
New coronal caries in permanent first molars (caries prevention) · Children with dental caries in permanent (first) molars
One-time ammonium bifluoride gave a 56% prevented fraction, similar to SDF (57%) (single study; ungraded).
1 finding from 1 review
Adverse events associated with treatment · Adults with oropharyngeal cancer
1 finding from 1 review
Adverse events: grade 2+ treatment-related events similar (31/34 radiotherapy vs 33/34 surgery; RR 0.94, 0.83 to 1.06); more hearing loss/neutropenia/constipation/tinnitus with radiotherapy, more oral bleeding/trismus…
1 study · 68 participants
Very low
Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment
Upper clear plastic retainer + lower fixed canine-to-canine retainer showed no clear difference in stability: Little's Irregularity Index (lower arch) compared with upper clear plastic retainer + lower interproximal reduction…; GRADE not reported.
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported insufficient scientific evidence to support an association between dental agenesis and oral health-related quality of life.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Early childhood caries (ECC) · Children aged ≤6 years (early childhood)
One Nigerian cross-sectional study reported a significant adjusted association between nutritional (stunting) status and ECC (APR 0.14, 95% CI 0.03-0.69); ungraded.
3 findings from 1 review
APR 0.14 [0.03, 0.69]
1 study · 370 participants
GRADE not reported
Correlation (r) -0.091
1 study · 82 participants
GRADE not reported
The bi-directional relationship between growth stunting and early childhood caries: a rapid review. 2023 All outcomes2-year follow-up · Ecuador (rural) · Sokal-Gutierrez et al. 2016 (Ecuador; pre vs post intervention)
Pre/post ECC prevalence, dmft, and deep-caries proportion (2-year follow-up) Age 1: prevalence 53.8% to 30.3%, dmft 2.1 to 0.9; Age 2: prevalence 82% to 60%, dmft 5.3 to 3.0, deep caries 19% to 12% (pre vs post)
1 study · 1575 participants
GRADE not reported
Oral health-related quality of life · Adolescents (10-19 years)
Complicated traumatic dental injuries (pulp exposure or tooth darkening) worsen OHRQoL in adolescents, while uncomplicated injuries show little impact (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
MMP-2 presence/activity · Human coronal carious dentin and sound dentin
MMP-2 may be increased in carious dentin compared with sound dentin (very low certainty).
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; permanent teeth
Over 1 year in permanent teeth, resin composite showed no statistically significant difference in secondary caries versus GIC (RR 3.05, 95% CI 0.95-9.79; low certainty).
1 finding from 1 review
Total mortality · Adults with oral cavity or oropharyngeal cancer
It is very uncertain whether surgery plus radiotherapy changes total mortality compared with radiotherapy alone (very low certainty).
1 finding from 1 review
Plaque · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Herbal mouthwash reduced some plaque-related indices versus placebo, with low-certainty evidence.
1 finding from 1 review