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Evidence found and GRADE certainty

3,556 questions · 10,375 findings · 429 reviews · All outcomes

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No studies found 1,344 · 13%GRADE not reported 6,832 · 65.9%Very low 1,228 · 11.8%Low 613 · 5.9%Moderate 290 · 2.8%High 68 · 0.7%

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Beta-thalassemia major vs Healthy Emirati children

Oral health status (caries, calculus, gingivitis) · Children with beta-thalassemia major in Dubai

One study found higher caries and calculus but lower gingivitis and restorative care in children with beta-thalassemia major compared with healthy Emirati children (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs Supra-gingival scaling

Systolic blood pressure (mmHg), change from baseline · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Intensive periodontal treatment (subgingival SRP with or without… probably leads to lower change in systolic blood pressure (SBP, mmHg) compared with supra-gingival scaling (moderate certainty).

3 findings from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs Supra-gingival scaling

Plasma level of hs-CRP (mg/L) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Intensive periodontal treatment (subgingival SRP with or without… showed no clear difference in plasma level of hs-CRP (mg/L) compared with supra-gingival scaling; GRADE not reported.

2 findings from 1 review

Blood and saliva analysis (biomarker tests) vs Surgical or punch biopsy with histological assessment

Outcome not reported · Adults (aged 16 years or over) presenting to primary or secondary care with clinically evident suspicious or innocuous oral lesions

The review found no eligible studies for this question.

1 finding from 1 review

ARP with xenograft (bone graft) vs Extraction alone

Implant failure rate · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

It is very uncertain whether ARP with xenograft (bone graft) changes implant failure rate compared with extraction alone (very low certainty).

1 finding from 1 review

Oral hygiene knowledge and practices assessment vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Oral hygiene knowledge and practices · Children and adolescents in the United Arab Emirates

Oral hygiene knowledge and practices among UAE children and adolescents were generally suboptimal and variable across studies, with better practices among females (narrative synthesis; not GRADE-rated).

1 finding from 1 review

COE with blood/salivary (biomarker) analysis vs COE with vital rinsing (toluidine blue/tolonium chloride)

Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…

The review found no eligible studies for this question.

1 finding from 1 review

Digital bitewing radiography, sensor-based (CCD/CMOS) vs Direct visual examination after tooth separation or bioptical cavity preparation

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)

Under in vivo conditions, sensor-based digital bitewing radiography had a pooled sensitivity of 0.96 (95% CI 0.91, 0.98) for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
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Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment)

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for ACVD-related events (13 studies, I2=75%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

3 findings from 1 review

Fixed tooth-borne expansion (quad-helix) vs Removable tooth-borne expansion (expansion plate)

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed tooth-borne expansion (quad-helix) leads to higher molar expansion (inter-molar distance) compared with removable tooth-borne expansion (expansion plate) (high certainty).

1 finding from 1 review

In-office laser therapy (all types combined) vs Placebo (placebo laser or placebo agent) or no treatment

Changes in intensity of pain (VAS 0 to 10) tested through tactile stimuli · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

It is very uncertain whether in-office laser therapy (all types combined) changes changes in intensity of pain (VAS 0 to 10) tested through tactile… compared with placebo (placebo laser or placebo agent) or no treatment (very low certainty).

3 findings from 1 review

Visual or visual-tactile classification systems (any system: ICDAS, ERK, Nyvad, Downer, Lussi, UniViSS, or unspecified) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Diagnostic accuracy in previously restored teeth (secondary caries) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
  • Visual or visual‐tactile examination to detect and inform the diagnosis of enamel caries 2021 · Cochrane All outcomes
    Up to 3 months between index test and reference standard (in vivo studies) · Previously restored teeth (secondary caries)
    Only one study (Kim 2017) intentionally included restored teeth in its sample; the pre-specified secondary-caries subgroup analysis could not be performed, no summary estimate reported.
    1 study
    GRADE not reported

Electronic caries monitor (ECM) device (ECM II / ECM III / ECM IV) vs Reference standard (histology, excavation, or enhanced visual examination)

Specificity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or extracted teeth of…
1 finding from 1 review

Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

Incidence of eruption of the PDC into the mouth · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

It is very uncertain whether extraction of the primary (baby) canine (single primary tooth… changes incidence of eruption of the PDC into the mouth compared with no extraction (non-intervention control) (very low certainty).

1 finding from 1 review

Self-ligating brackets vs Conventional brackets

Time to alignment · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Self-ligating brackets showed no clear difference in time to alignment (days) compared with conventional brackets; GRADE not reported.

1 finding from 1 review

Cervical pull headgear vs Minor interceptive procedures (control)

Position of the incisors (upper incisor inclination) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Cervical pull headgear led to higher upper incisors to maxilla at 2 years compared with minor interceptive procedures (control); GRADE not reported.

1 finding from 1 review

Resin infiltration vs Fluoride varnish

Optical/esthetic improvement (DIAGNOdent reading) · Patients (mainly children) with white spot lesions (WSL)

Resin infiltration produced significantly greater optical improvement than fluoride varnish (MD 4.76, 95% CI 0.74 to 8.78; moderate certainty).

3 findings from 1 review