Findings

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Evidence found and GRADE certainty

3,323 questions · 5,762 findings · 263 reviews · Dental caries

No studies found 321 · 5.6%GRADE not reported 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

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Electronic caries monitor (ECM) device (ECM II / ECM III / ECM IV) vs Reference standard (histology, excavation, or enhanced visual examination)

Specificity · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or extracted teeth of…
1 finding from 1 review

Resin infiltration vs Fluoride varnish

Optical/esthetic improvement (DIAGNOdent reading) · Patients (mainly children) with white spot lesions (WSL)

Resin infiltration produced significantly greater optical improvement than fluoride varnish (MD 4.76, 95% CI 0.74 to 8.78; moderate certainty).

3 findings from 1 review

Sealing using sealant materials vs Selective carious tissue removal (selective excavation, SE)

Lesion progression · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
1 finding from 1 review
  • Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes
    Cavitated lesions, primary dentition
    Lesion progression reported narratively: Dias 2018 1/27 sealed vs 1/21 SE at 24 months; Hesse 2014 0/17 sealed vs 0/17 SE at 18 months; not pooled and not GRADE-rated.
    2 studies
    GRADE not reported

Electrical conductance devices (electronic caries monitor (ECM) and/or CarieScan Pro), used as an adjunct to clinical oral examination vs Reference standard (histology, excavation, or enhanced visual examination)

Diagnostic odds ratio (overall test accuracy) · Children, adolescents, or adults presenting asymptomatically or suspected of early enamel caries (in vivo), or extracted teeth of…
1 finding from 1 review

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Percentage of bleeding on probing (BOP) · Adults undergoing orthodontic treatment

No clear difference in bleeding on probing between aligners and fixed appliances in adults at 6-12 weeks (MD -0.26, 95% CI -0.77 to 0.26; very low certainty).

1 finding from 1 review

Quantitative light-induced fluorescence (QLF) vs Histological validation (in vitro) or cavity preparation/biopsy (in vivo)

Occlusal caries detection accuracy · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

No eligible QLF studies met the meta-analysis inclusion criteria (candidate QLF studies were identified but none had acceptable index/reference tests and reporting quality).

1 finding from 1 review

Intervention not reported

Relative abundance of Veillonella spp.

The intervention showed no clear difference in relative abundance of Veillonella spp.; GRADE not reported.

1 finding from 1 review

Selective carious tissue removal (selective excavation, SE) vs Stepwise carious tissue removal (SW)

Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

Selective carious tissue removal (selective excavation, SE) probably leads to higher failure of therapy compared with stepwise carious tissue removal (SW) (moderate certainty).

2 findings from 1 review

COE with blood/salivary (biomarker) analysis vs Conventional oral examination (COE) alone

Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…

The review found no eligible studies for this question.

1 finding from 1 review

Sealant (any type) vs No sealant (control/no treatment)

Initiation of white spot lesions (WSL), visual-tactile assessment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Sealant use reduced the incidence of new white spot lesions versus no sealant (very low certainty).

1 finding from 1 review

Dental imaging (analog or digital radiographs) vs Visual classification

Difference in specificity · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies)

Imaging and visual classification had similar specificity in the fully within-person analysis.

1 finding from 1 review

Inflammatory bowel disease (IBD) vs Healthy controls without IBD

Periodontal disease (periodontitis) coincidence · Patients with inflammatory bowel disease (IBD) and controls without IBD; mostly adults (one pediatric study), both sexes

Patients with IBD have about 2.5-fold higher odds of coexisting periodontal disease than healthy controls (pooled OR 2.49, 95% CI 1.97-3.15; 6 studies; not GRADE-rated).

1 finding from 1 review

Intervention not reported

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years)

Caries prevalence was highest in the Tigray region at 46.59% (95% CI 24.64 to 68.54); certainty not graded.

1 finding from 1 review

Fibre-optic transillumination (FOTI) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

In in vitro, fibre-optic transillumination pooled sensitivity was 0.97 (95% CI -0.92 to 0.99) for occlusal caries at the caries detection level; ungraded.

4 findings from 1 review
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Non-selective carious tissue removal and conventional restoration (CR) vs Hall Technique (sealing with a preformed metal crown)

Efficiency, costs or cost-effectiveness · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
1 finding from 1 review