What do systematic reviews say?

Cyclophosphamide vs placebo

• Cyclophosphamide for connective tissue disease–associated interstitial lung disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 158 participants
  Moderate

Glyceryl trinitrate (GTN) vs no GTN

• Nitric oxide donors (nitrates), L‐arginine, or nitric oxide synthase inhibitors for acute stroke 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 4088 participants
  High

Intervention not reported

• Deep brain and cortical stimulation for epilepsy 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 4 participants
  Low

Glycerol laxative vs acupuncture

The review found no eligible studies for this question.

• Pharmacological treatment for antipsychotic‐related constipation 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Mannitol vs phenolphthalein or rhubarb soda

The review found no eligible studies for this question.

• Pharmacological treatment for antipsychotic‐related constipation 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Glycerol laxative vs tuina massage

The review found no eligible studies for this question.

• Pharmacological treatment for antipsychotic‐related constipation 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Interferon vs no intervention

It is very uncertain whether interferon changes health‐related quality of life (1 week) compared with no intervention (very low certainty).

• Pharmacological interventions for acute hepatitis B infection 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Very low

Lamivudine vs no intervention

The review found no eligible studies for this question.

• Pharmacological interventions for acute hepatitis B infection 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Experimental chewing adjuncts (bite wafers or chewing gum) vs No chewing gum, placebo, or control (no adjunct)

Experimental chewing adjuncts (bite wafers or chewing gum) led to lower quality of life or patient satisfaction compared with no chewing gum, placebo, or control (no adjunct); GRADE not reported.

• Non‐pharmacological interventions for alleviating pain during orthodontic treatment 2016 · Cochrane All outcomes

  24 hours
  RR 0.45 [0.22, 0.94]
  2 studies · 107 participants
  GRADE not reported

Intervention not reported

• Interactive telemedicine: effects on professional practice and health care outcomes 2015 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 482 participants
  Moderate

BRIEF CBT vs STANDARD DURATION CBT

• Cognitive behavioural therapy (brief versus standard duration) for schizophrenia 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Stopping LABA vs continuing use of LABA+ICS

• Stopping long‐acting beta₂‐agonists (LABA) for adults with asthma well controlled by LABA and inhaled corticosteroids 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 359 participants
  Moderate

Antibiotics vs placebo

• Antibiotics for acute maxillary sinusitis in adults 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Other types of high tibial osteotomy (aHTO) vs closing wedge high tibial osteotomy (CW‐HTO)

The review found no eligible studies for this question.

• Osteotomy for treating knee osteoarthritis 2014 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Uncemented fixation with and without hydroxyapatite vs cemented fixation

• Cemented, cementless or hybrid fixation options in total knee arthroplasty for osteoarthritis and other non‐traumatic… 2012 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Periodontal disease assessed by Community Periodontal Index (CPI) vs No periodontal disease assessed by community periodontal index

Results were inconsistent and certainty was very low.

• Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and Meta-analysis. 2023 All outcomes

  India
  no estimate extracted
  3 studies · 1345 participants
  Very low

Malocclusion vs No malocclusion

Malocclusion is associated with poor OHRQoL but certainty is very low.

• Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and Meta-analysis. 2023 All outcomes

  India
  OR 5.44 [1.61, 18.39]
  6 studies · 3720 participants
  Very low

Prosthetic need vs Individuals without prosthetic need

Prosthetic need is associated with poor OHRQoL (moderate certainty).

• Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and Meta-analysis. 2023 All outcomes

  India
  no estimate extracted
  2 studies · 950 participants
  Moderate

Summary of findings table ‐ Oral classical immunosuppressants (prednisolone or cyclosporine) vs placebo

• Treatments for alopecia areata: a network meta‐analysis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 36 participants
  Very low

Gingivitis (assessed by gingival index or WHO criteria) vs Individuals without gingivitis

Results were inconsistent and certainty was very low.

• Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and Meta-analysis. 2023 All outcomes

  India
  no estimate extracted
  3 studies · 943 participants
  Very low