Cochrane · systematic review · CD000398
Nitric oxide donors (nitrates), L‐arginine, or nitric oxide synthase inhibitors for acute stroke
Bath, PMW, Krishnan, K, Appleton, JP · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
StrokeAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 7 · 100%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Glyceryl trinitrate (GTN) compared with no GTN for acute stroke
Population: people with acute stroke
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death or dependency (mRS>2), end of trial (90 days) Glyceryl trinitrate (GTN) vs no GTN | OR 0.97 [0.86, 1.1] | 5 studies · 4195 participants | High |
Death, end of trial (90 days) Glyceryl trinitrate (GTN) vs no GTN | OR 0.78 [0.4, 1.5] | 5 studies · 4197 participants | High |
Quality of life, end of trial (90 days) Glyceryl trinitrate (GTN) vs no GTN | no estimate extracted | 4 studies · 4088 participants | High |
Systolic BP, first treatment measurement (<24 hours after randomisation) Glyceryl trinitrate (GTN) vs no GTN | no estimate extracted | 5 studies · 4197 participants | High |
Diastolic BP, first treatment measurement (<24 hours after randomisation) Glyceryl trinitrate (GTN) vs no GTN | no estimate extracted | 5 studies · 4197 participants | High |
Heart rate, first treatment measurement (<24 hours after randomisation) Glyceryl trinitrate (GTN) vs no GTN | no estimate extracted | 5 studies · 4197 participants | High |
Adverse event: Headache, on treatment (7‐12 days) Glyceryl trinitrate (GTN) vs no GTN | OR 2.37 [1.55, 3.62] | 5 studies · 4186 participants | High |