Cochrane · systematic review · CD011128
Pharmacological treatment for antipsychotic‐related constipation
Every‐Palmer, S, Newton‐Howes, G, Clarke, MJ · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
35
current version
GRADE rated
5
No studies
29
Included studies
NR
No studies 29 · 82.9%Ungraded 1 · 2.9%Very low 5 · 14.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Glycerol laxative versus tuina massage for antipsychotic‐related constipation
Population: antipsychotic‐related constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global or clinical change in constipation (a) as defined by the study Still constipated (no defecation) at 2 days Glycerol laxative vs tuina massage | RR 2.88 [1.89, 4.39] | 1 study · 120 participants | Very low Downgraded: risk of bias |
Global or clinical change in constipation (a) as defined by the study Still constipated (no defecation) at 3 days Glycerol laxative vs tuina massage | RR 4.8 [1.96, 11.74] | 1 study · 120 participants | Very low Downgraded: risk of bias |
(b) Change in the frequency of defecation Glycerol laxative vs tuina massage | no estimate extracted | NR | No studies |
(c) Change in straining at defecation Glycerol laxative vs tuina massage | no estimate extracted | NR | No studies |
(d) Change in the frequency of lumpy or hard stools Glycerol laxative vs tuina massage | no estimate extracted | NR | No studies |
(e) Change in the frequency of manual manoeuvres to facilitate defecation Glycerol laxative vs tuina massage | no estimate extracted | NR | No studies |
Need for rescue medication Glycerol laxative vs tuina massage | no estimate extracted | NR | No studies |
Presence of antipsychotic‐related constipation complications such as bowel obstruction Glycerol laxative vs tuina massage | no estimate extracted | NR | No studies |
Quality of life (changed to any extent) Glycerol laxative vs tuina massage | no estimate extracted | NR | No studies |
Adverse events Glycerol laxative vs tuina massage | no estimate extracted | NR | No studies |
Leaving the study early Glycerol laxative vs tuina massage | no estimate extracted | NR | No studies |
Economic costs Glycerol laxative vs tuina massage | no estimate extracted | NR | No studies |
Glycerol laxative versus acupuncture for antipsychotic‐related constipation
Population: antipsychotic‐related constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global or clinical change in constipation (a) as defined by the study Still constipated (no defecation) at 2 days Glycerol laxative vs acupuncture | RR 3.5 [2.18, 5.62] | 1 study · 120 participants | Very low Downgraded: risk of bias |
Still constipated (no defecation) at 3 days Glycerol laxative vs acupuncture | RR 8 [2.54, 25.16] | 1 study · 120 participants | Very low Downgraded: risk of bias |
(b) Change in the frequency of defecation Glycerol laxative vs acupuncture | no estimate extracted | NR | No studies |
(c) Change in straining at defecation Glycerol laxative vs acupuncture | no estimate extracted | NR | No studies |
(d) Change in the frequency of lumpy or hard stools Glycerol laxative vs acupuncture | no estimate extracted | NR | No studies |
(e) Change in the frequency of manual manoeuvres to facilitate defecation Glycerol laxative vs acupuncture | no estimate extracted | NR | No studies |
Need for rescue medication Glycerol laxative vs acupuncture | no estimate extracted | NR | No studies |
Presence of antipsychotic‐related constipation complications such as bowel obstruction Glycerol laxative vs acupuncture | no estimate extracted | NR | No studies |
Quality of life (changed to any extent) Glycerol laxative vs acupuncture | no estimate extracted | NR | No studies |
Adverse events Glycerol laxative vs acupuncture | no estimate extracted | NR | No studies |
Leaving the study early Glycerol laxative vs acupuncture | no estimate extracted | NR | No studies |
Economic costs Glycerol laxative vs acupuncture | no estimate extracted | NR | No studies |
Mannitol versus phenolphthalein or rhubarb soda for antipsychotic‐related constipation
Population: antipsychotic‐related constipation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global or clinical change in constipation as defined by the study a) Still constipated (no defecation) at 24 hours Mannitol vs phenolphthalein or rhubarb soda | RR 0.07 [0.02, 0.27] | 1 study · 240 participants | Very low Downgraded: risk of bias |
(b) Change in the frequency of defecation Mannitol vs phenolphthalein or rhubarb soda | no estimate extracted | NR | No studies |
(c) Change in straining at defecation Mannitol vs phenolphthalein or rhubarb soda | no estimate extracted | NR | No studies |
(d) Change in the frequency of lumpy or hard stools Mannitol vs phenolphthalein or rhubarb soda | no estimate extracted | NR | No studies |
(e) Change in the frequency of manual manoeuvres to facilitate defecation Mannitol vs phenolphthalein or rhubarb soda | no estimate extracted | NR | No studies |
Need for rescue medication Mannitol vs phenolphthalein or rhubarb soda | no estimate extracted | NR | No studies |
Presence of antipsychotic‐related constipation complications such as bowel obstruction Mannitol vs phenolphthalein or rhubarb soda | no estimate extracted | NR | No studies |
Quality of life (changed to any extent) Mannitol vs phenolphthalein or rhubarb soda | no estimate extracted | NR | No studies |
Adverse events Mannitol vs phenolphthalein or rhubarb soda | no estimate extracted | 1 study · 240 participants | Ungraded |
Leaving the study early Mannitol vs phenolphthalein or rhubarb soda | no estimate extracted | NR | No studies |
Economic costs Mannitol vs phenolphthalein or rhubarb soda | no estimate extracted | NR | No studies |