Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

68 questions · 71 findings · 38 reviews · Heart

No studies found 16 · 22.5%GRADE not reported 2 · 2.8%Very low 8 · 11.3%Low 17 · 23.9%Moderate 21 · 29.6%High 7 · 9.9%

Transcatheter aortic valve implantation vs surgical aortic valve replacement

Myocardial infarction · adults with severe aortic stenosis who are at a low surgical risk.

Transcatheter aortic valve implantation showed no clear difference in myocardial infarction compared with surgical aortic valve replacement (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Myocardial infarction · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in myocardial infarction compared with placebo or standard care (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Myocardial infarction · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in myocardial infarction compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Routine invasive strategies vs selective invasive strategies (conservative)

Myocardial infarction · participants with UA/NSTEMI in the stent era

Routine invasive strategies showed no clear difference in myocardial infarction compared with selective invasive strategies (conservative) (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Myocardial infarction · patients with coronary heart disease

Antibiotics showed no clear difference in myocardial infarction at 24±6 months compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Intervention not reported

Myocardial infarction at maximum · patients without heart failure

The intervention probably leads to lower myocardial infarction at maximum (moderate certainty).

1 finding from 1 review

Beta‐blockers vs placebo or no intervention

Myocardial infarction · patients with suspected or diagnosed myocardial infarction

Beta‐blockers showed no clear difference in myocardial infarction at maximum compared with placebo or no intervention (low certainty).

2 findings from 1 review

Intervention not reported

Myocardial infarction (non‐fatal) · people with cardiovascular disease or at high risk of cardiovascular disease

The intervention probably leads to lower myocardial infarction (non‐fatal) (moderate certainty).

1 finding from 1 review