Cochrane · systematic review · CD008684
Coenzyme Q10 for heart failure
Al Saadi, T, Assaf, Y, Farwati, M, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 3 · 42.9%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Coenzyme Q10 compared to placebo or conventional therapy for heart failure
Population: people with heart failure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Coenzyme Q10 vs placebo or conventional therapy | RR 0.58 [0.35, 0.95] | 1 study · 420 participants | Moderate Downgraded: imprecision, indirectness |
Myocardial infarction Coenzyme Q10 vs placebo or conventional therapy | RR 1.62 [0.27, 9.59] | 1 study · 420 participants | Low Downgraded: imprecision, indirectness |
Stroke Coenzyme Q10 vs placebo or conventional therapy | RR 0.18 [0.02, 1.48] | 1 study · 420 participants | Low Downgraded: imprecision, indirectness |
Hospitalisation for heart failure Coenzyme Q10 vs placebo or conventional therapy | RR 0.62 [0.49, 0.78] | 2 studies · 1061 participants | Moderate Downgraded: risk of bias |
Left ventricular ejection fraction (%) Coenzyme Q10 vs placebo or conventional therapy | no estimate extracted | 7 studies · 650 participants | Very low Downgraded: risk of bias, imprecision |
Exercise capacity( Coenzyme Q10 vs placebo or conventional therapy | no estimate extracted | 3 studies · 91 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Coenzyme Q10 vs placebo or conventional therapy | RR 0.7 [0.45, 1.1] | 2 studies · 568 participants | Low Downgraded: imprecision, indirectness |