Cochrane · systematic review · CD003610
Antibiotics for secondary prevention of coronary heart disease
Sethi, NJ, Safi, S, Korang, SK, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
10
No studies
4
Included studies
NR
No studies 4 · 28.6%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 28.6%High 6 · 42.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotics versus placebo or no intervention for secondary prevention of patients with coronary heart disease at maximum follow‐up
Population: patients with coronary heart disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality at maximum Antibiotics vs placebo or no intervention | RR 1.06 [0.99, 1.13] | 20 studies · 25774 participants | High |
Serious adverse event at maximum Antibiotics vs placebo or no intervention | no estimate extracted | NR | No studies |
Quality of life at maximum Antibiotics vs placebo or no intervention | no estimate extracted | NR | No studies |
Cardiovascular mortality at maximum Antibiotics vs placebo or no intervention | RR 1.11 [0.98, 1.25] | 2 studies · 4674 participants | Moderate Downgraded: imprecision, indirectness |
Myocardial infarction at maximum Antibiotics vs placebo or no intervention | RR 0.95 [0.88, 1.03] | 17 studies · 25523 participants | High |
Stroke at maximum Antibiotics vs placebo or no intervention | RR 1.14 [1, 1.29] | 9 studies · 14774 participants | High |
Sudden cardiac death at maximum Antibiotics vs placebo or no intervention | RR 1.08 [0.9, 1.31] | 2 studies · 4520 participants | Moderate Downgraded: imprecision, indirectness |
Antibiotics versus placebo or no intervention for secondary prevention of patients with coronary heart disease at 24±6 months follow‐up
Population: patients with coronary heart disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality at 24±6 months Antibiotics vs placebo or no intervention | RR 1.25 [1.06, 1.48] | 6 studies · 9517 participants | High |
Serious adverse event at 24±6 months Antibiotics vs placebo or no intervention | no estimate extracted | NR | No studies |
Quality of life at 24±6 months Antibiotics vs placebo or no intervention | no estimate extracted | NR | No studies |
Cardiovascular mortality at 24±6 months Antibiotics vs placebo or no intervention | RR 1.5 [1.17, 1.91] | 5 studies · 9044 participants | High |
Myocardial infarction at 24±6 months Antibiotics vs placebo or no intervention | RR 0.95 [0.82, 1.11] | 5 studies · 9457 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Stroke at 24±6 months Antibiotics vs placebo or no intervention | RR 1.17 [0.9, 1.52] | 5 studies · 9457 participants | High |
Sudden cardiac death at 24±6 months Antibiotics vs placebo or no intervention | RR 1.77 [1.28, 2.44] | 2 studies · 4520 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |