Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

75 questions · 84 findings · 35 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 2 · 2.4%GRADE not reported 3 · 3.6%Very low 27 · 32.1%Low 31 · 36.9%Moderate 13 · 15.5%High 8 · 9.5%

Direct oral anticoagulant (DOAC) prophylaxis vs no prophylaxis

All‐cause mortality · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Direct oral anticoagulant (DOAC) prophylaxis showed no clear difference in mortality compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

All‐cause mortality · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis showed no clear difference in mortality compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution

All‐cause mortality · febrile neutropenia

Early discontinuation of antibiotic treatment showed no clear difference in mortality compared with treatment until neutropenia resolution (low certainty).

1 finding from 1 review

Probiotics vs placebo

All‐cause mortality · participants with cancer treated with radiotherapy (with or without chemotherapy)
2 findings from 1 review

Heparin prophylaxis vs no prophylaxis

All‐cause mortality

Heparin prophylaxis showed no clear difference in mortality compared with no prophylaxis (moderate certainty).

2 findings from 1 review