Cochrane · systematic review · CD009031
Outpatient treatment for people with cancer who develop a low‐risk febrile neutropaenic event
Rivas‐Ruiz, R, Villasis‐Keever, M, Miranda‐Novales, G, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
13
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 8 · 61.5%Moderate 5 · 38.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Outpatients compared to inpatients ‐ adults for people with cancer who develop a low‐risk febrile neutropaenic event
Population: Adult patients with cancer who develop a low‐risk febrile neutropaenic event
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment failure Outpatients vs inpatients ‐ adults | RR 1.23 [0.82, 1.85] | 6 studies · 628 participants | Moderate Downgraded: risk of bias, imprecision |
Mortality Outpatients vs inpatients ‐ adults | RR 1.04 [0.29, 3.71] | 6 studies · 628 participants | Moderate Downgraded: risk of bias, imprecision |
Duration of fever (days) Outpatients vs inpatients ‐ adults | no estimate extracted | 1 study · 169 participants | Low Downgraded: risk of bias |
Adverse drugs reactions Outpatients vs inpatients ‐ adults | RR 8.39 [0.38, 187.15] | 3 studies · 375 participants | Low Downgraded: risk of bias, imprecision |
Duration of neutropaenia (days) Outpatients vs inpatients ‐ adults | no estimate extracted | 1 study · 169 participants | Low Downgraded: risk of bias |
Duration of hospitalisation (days) Outpatients vs inpatients ‐ adults | no estimate extracted | 3 studies · 251 participants | Low Downgraded: risk of bias, imprecision |
Outpatients compared to inpatients ‐ children for people with cancer who develop a low‐risk febrile neutropaenic event
Population: Children with cancer who develop a low‐risk febrile neutropaenic event
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment failure Outpatients vs inpatients ‐ children | RR 1.04 [0.55, 1.99] | 4 studies · 366 participants | Moderate Downgraded: risk of bias, imprecision |
Mortality Outpatients vs inpatients ‐ children | RR 0.63 [0.15, 2.7] | 3 studies · 329 participants | Moderate Downgraded: risk of bias, imprecision |
Duration of fever (days) Outpatients vs inpatients ‐ children | no estimate extracted | 3 studies · 305 participants | Low Downgraded: risk of bias, imprecision |
Adverse drug reactions Outpatients vs inpatients ‐ children | RR 1.9 [0.61, 5.98] | 2 studies · 156 participants | Low Downgraded: risk of bias, imprecision |
Duration of neutropaenia (days) Outpatients vs inpatients ‐ children | no estimate extracted | 2 studies · 268 participants | Moderate Downgraded: risk of bias, imprecision |
Duration of hospitalisation (days) Outpatients vs inpatients ‐ children | no estimate extracted | 1 study · 119 participants | Low Downgraded: risk of bias |
Duration of antimicrobial treatment (days) Outpatients vs inpatients ‐ children | no estimate extracted | 3 studies · 305 participants | Low Downgraded: risk of bias, imprecision, inconsistency |