Cochrane · systematic review · CD010604
Pharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults
van den Blink, QU, Garcez, K, Henson, CC, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Pharmacological intervention compared with no intervention for prevention of radiation‐related insufficiency fractures and avascular necrosis
Population: Adults undergoing pelvic radiotherapy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Insufficiency fractures and avascular necrosis Pharmacological intervention vs no intervention | no estimate extracted | 905 participants | Very low |
BMD and fracture risk Pharmacological intervention vs no intervention | no estimate extracted | 905 participants | Very low |
Bone turnover markers Pharmacological intervention vs no intervention | no estimate extracted | 905 participants | Very low |
QoL Pharmacological intervention vs no intervention | no estimate extracted | 905 participants | Very low |
Mortality Pharmacological intervention vs no intervention | no estimate extracted | 905 participants | Very low |
Adverse events Pharmacological intervention vs no intervention | no estimate extracted | 905 participants | Very low |