Cochrane · systematic review · CD012184
Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer
Stern, A, Carrara, E, Bitterman, R, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 66.7%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Early discontinuation of antibiotic treatment compared to treatment until neutropenia resolution for febrile neutropenia
Population: febrile neutropenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution | RR 1.38 [0.73, 2.62] | 8 studies · 603 participants | Low Downgraded: risk of bias, imprecision |
Clinical failure Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution | RR 1.23 [0.85, 1.77] | 7 studies · 645 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Any bacteraemia Early discontinuation of antibiotic treatment vs treatment until neutropenia resolution | RR 1.56 [0.91, 2.66] | 8 studies · 662 participants | Very low Downgraded: risk of bias, imprecision |