Cochrane · systematic review · CD005007
Hyperbaric oxygenation for tumour sensitisation to radiotherapy
Bennett, MH, Feldmeier, J, Smee, R, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
12
No studies
6
Included studies
NR
No studies 6 · 33.3%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 4 · 22.2%High 8 · 44.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Hyperbaric oxygen versus air breathing to enhance the effectiveness of radiotherapy for tumours of the head and neck
Population: People undergoing radiation therapy for head and neck cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy | RR 0.83 [0.7, 0.98] | 9 studies · 710 participants | High |
Failure of local tumour control (local control) Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy | RR 0.58 [0.39, 0.85] | 4 studies · 446 participants | Moderate Downgraded: imprecision |
Local recurrence (recurrence ) Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy | RR 0.66 [0.56, 0.78] | 5 studies · 582 participants | High |
Metastasis Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy | RR 0.45 [0.09, 2.3] | 1 study · 50 participants | Moderate Downgraded: imprecision |
Quality of life ‐ not reported Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy | no estimate extracted | NR | No studies |
Adverse effects Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy | RR 2.64 [1.65, 4.23] | 4 studies · 323 participants | Moderate Downgraded: imprecision |
Hyperbaric oxygen compared to air breathing for enhancing the effect of radiation for cancer of the uterine cervix
Population: People undergoing radiotherapy for uterine cervical cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Hyperbaric oxygen vs air breathing | RR 0.88 [0.69, 1.11] | 4 studies · 728 participants | High |
Failure of local tumour control ‐ not reported Hyperbaric oxygen vs air breathing | no estimate extracted | NR | No studies |
Local recurrence (recurrence) Hyperbaric oxygen vs air breathing | RR 0.82 [0.63, 1.06] | 3 studies · 714 participants | High |
Metastasis Hyperbaric oxygen vs air breathing | RR 1.05 [0.84, 1.31] | 3 studies · 520 participants | High |
Quality of life ‐ not reported Hyperbaric oxygen vs air breathing | no estimate extracted | NR | No studies |
Adverse effects Hyperbaric oxygen vs air breathing | RR 2.05 [1.22, 3.46] | 3 studies · 456 participants | High |
Hyperbaric oxygen compared to air breathing for enhancing the effect of radiotherapy for a mixed group of cancers (urinary bladder, lung, rectum, oesophagus, brain)
Population: People with any one of a mixed group of cancers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality with urinary bladder cancer Hyperbaric oxygen vs air breathing | RR 0.97 [0.74, 1.27] | 4 studies · 330 participants | High |
Failure of local tumour control ‐ not reported Hyperbaric oxygen vs air breathing | no estimate extracted | NR | No studies |
Local recurrence ‐ not reported Hyperbaric oxygen vs air breathing | no estimate extracted | NR | No studies |
Metastases with urinary bladder cancer Hyperbaric oxygen vs air breathing | RR 2 [0.58, 6.91] | 2 studies · 80 participants | Moderate Downgraded: imprecision |
Quality of life ‐ not reported Hyperbaric oxygen vs air breathing | no estimate extracted | NR | No studies |
Adverse effects Hyperbaric oxygen vs air breathing | RR 2.35 [1.66, 3.33] | 7 studies · 779 participants | High |