Summary of Findings Table ‐ DaxibotulinumtoxinA 40U vs placebo
Major adverse events · glabellar lines
1 finding from 1 review
- no estimate extracted2 studies · 716 participantsModerate
Findings
What do systematic reviews say?
62 questions · 64 findings · 30 reviews
No studies found 12 · 18.8%GRADE not reported 0 · 0%Very low 26 · 40.6%Low 11 · 17.2%Moderate 15 · 23.4%High 0 · 0%
Intervention not reported
Major adverse events · for effects on cramps, people (other than pregnant women) with muscle cramps (largely older adults); for adverse events, all populations
It is very uncertain whether the intervention changes major adverse events (very low certainty).
1 finding from 1 review
- RR 0.68 [0.14, 3.31]3 studies · 185 participantsVery low
Mechanical assist devices vs intra‐aortic balloon pump
Major adverse events · people with acute cardiogenic shock
1 finding from 1 review
- no estimate extracted3 studies · 122 participantsVery low
Convective radiofrequency water vapour thermal therapy vs sham
Major adverse events · men with lower urinary tract symptoms suggesting benign prostatic hyperplasia
It is very uncertain whether convective radiofrequency water vapour thermal therapy changes major adverse events compared with sham procedure (very low certainty).
1 finding from 1 review
- Convective radiofrequency water vapour thermal therapy for lower urinary tract symptoms in men with benign prostatic… 2020 · Cochrane Headline outcomes onlyRR 6.79 [0.39, 117]1 study · 197 participantsVery low
PUL vs sham
Major adverse events
It is very uncertain whether PUL changes major adverse events compared with sham (very low certainty).
1 finding from 1 review
- Prostatic urethral lift for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2019 · Cochrane Headline outcomes onlyRR 3.3 [0.41, 26.28]1 study · 206 participantsVery low
PUL vs TURP
Major adverse events
It is very uncertain whether PUL changes major adverse events compared with TURP (very low certainty).
2 findings from 1 review
- Prostatic urethral lift for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2019 · Cochrane Headline outcomes onlyRR 0.64 [0.18, 2.19]1 study · 79 participantsVery low
- Prostatic urethral lift for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2019 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Aquablation vs transurethral resection of the prostate
Major adverse events · men with benign prostatic hyperplasia
It is very uncertain whether aquablation changes major adverse events compared with transurethral resection of the prostate (very low certainty).
1 finding from 1 review
- Aquablation of the prostate for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia 2019 · Cochrane Headline outcomes onlyRR 0.84 [0.31, 2.26]1 study · 181 participantsVery low
Whole gland primary cryotherapy vs external beam radiotherapy (EBRT)
Major adverse events
It is very uncertain whether whole gland primary cryotherapy changes major adverse events compared with external beam radiotherapy (EBRT) (very low certainty).
1 finding from 1 review
- Primary cryotherapy for localised or locally advanced prostate cancer 2018 · Cochrane Headline outcomes onlyRR 0.91 [0.47, 1.78]2 studies · 293 participantsVery low
Alpha‐blockers vs usual care
Major adverse events · adult patients presenting with symptoms of ureteral stone disease
Alpha‐blockers showed no clear difference in major adverse events compared with standard therapy (low certainty).
1 finding from 1 review
- Alpha‐blockers as medical expulsive therapy for ureteral stones 2018 · Cochrane Headline outcomes onlyRR 1.25 [0.8, 1.96]18 studies · 3124 participantsLow
Alpha‐blockers vs placebo
Major adverse events · adult patients presenting with symptoms of ureteral stone disease
Alpha‐blockers probably leads to higher major adverse events compared with placebo (moderate certainty).
1 finding from 1 review
- Alpha‐blockers as medical expulsive therapy for ureteral stones 2018 · Cochrane Headline outcomes onlyRR 2.09 [1.13, 3.86]10 studies · 1650 participantsModerate
Desmopressin vs placebo
Major adverse events
Desmopressin showed no clear difference in major adverse events compared with placebo (low certainty).
2 findings from 1 review
- RR 3.05 [0.13, 73.39]1 study · 115 participantsLow
- RR 0.97 [0.1, 9.03]2 studies · 536 participantsVery low
Desmopressin vs alpha‐blocker
Major adverse events
1 finding from 1 review
- no estimate extracted1 study · 31 participantsLow
Desmopressin plus alpha‐blocker vs alpha‐blocker
Major adverse events
Desmopressin plus alpha‐blocker showed no clear difference in major adverse events compared with alpha‐blocker (low certainty).
1 finding from 1 review
- RR 0.3 [0.01, 7.32]3 studies · 402 participantsLow
Desmopressin plus alpha‐blocker vs alpha‐blocker plus anticholinergic
Major adverse events
1 finding from 1 review
- no estimate extracted1 study · 427 participantsLow
Alvimopan vs placebo
Major adverse events
Alvimopan probably leads to lower major adverse events compared with placebo (moderate certainty).
1 finding from 1 review
- Alvimopan for recovery of bowel function after radical cystectomy 2017 · Cochrane Headline outcomes onlyRR 0.28 [0.18, 0.44]1 study · 277 participantsModerate
Acupuncture vs medication
Major adverse events · Adults with overactive bladder (OAB)
1 finding from 1 review
- no estimate extracted14 studies · 927 participantsLow
Acupuncture vs no treatment
Major adverse events · Adults with overactive bladder (OAB)
1 finding from 1 review
- no estimate extracted1 study · 24 participantsVery low
Acupuncture vs sham
Major adverse events · Adults with overactive bladder (OAB)
1 finding from 1 review
- no estimate extracted5 studies · 236 participantsLow
Intervention not reported
Major adverse limb events (MALE) · people with intermittent claudication
The review found no eligible studies for this question.
1 finding from 1 review
- Mobile health technologies to improve walking distance in people with intermittent claudication 2024 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Percutaneous patellar osteosynthesis vs open surgery
Major adverse outcome: total events · adults with fractures of the patella
It is very uncertain whether percutaneous patellar osteosynthesis changes major adverse outcome: total events compared with open surgery (very low certainty).
1 finding from 1 review
- Interventions for treating fractures of the patella in adults 2021 · Cochrane Headline outcomes onlyRR 0.26 [0.14, 0.46]3 studies · 145 participantsVery low