Cochrane · systematic review · CD012111
Alvimopan for recovery of bowel function after radical cystectomy
Sultan, S, Coles, B, Dahm, P · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Alvimopan compared to placebo for recovery of bowel function after radical cystectomy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time‐to‐tolerance of a solid diet and documented bowel movements Alvimopan vs placebo | HR 1.77 [1.41, 2.23] | 1 study · 277 participants | Moderate Downgraded: imprecision |
Time‐to‐hospital discharge Alvimopan vs placebo | HR 1.67 [1.38, 2.01] | 1 study · 277 participants | Moderate Downgraded: imprecision |
Major adverse events Alvimopan vs placebo | RR 0.28 [0.18, 0.44] | 1 study · 277 participants | Moderate Downgraded: imprecision, indirectness |
Readmission Alvimopan vs placebo | RR 0.89 [0.59, 1.33] | 1 study · 277 participants | Moderate Downgraded: imprecision, indirectness |
Any cardiovascular event Alvimopan vs placebo | RR 0.54 [0.27, 1.05] | 1 study · 277 participants | Moderate Downgraded: imprecision, indirectness |