Cochrane · systematic review · CD005010
Primary cryotherapy for localised or locally advanced prostate cancer
Jung, JH, Risk, MC, Goldfarb, R, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
UrologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 6 · 85.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Whole gland primary cryotherapy compared to external beam radiotherapy (EBRT) for localised or locally advanced prostate cancer (long‐term outcomes)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to death from prostate cancer (absolute effects: disease‐specific mortality) Whole gland primary cryotherapy vs external beam radiotherapy (EBRT) | HR 1 [0.11, 9.45] | 2 studies · 293 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Quality of life ‐ urinary function Whole gland primary cryotherapy vs external beam radiotherapy (EBRT) | no estimate extracted | 1 study · 195 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Quality of life ‐ bowel function Whole gland primary cryotherapy vs external beam radiotherapy (EBRT) | no estimate extracted | 1 study · 195 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Quality of life ‐ sexual function Whole gland primary cryotherapy vs external beam radiotherapy (EBRT) | no estimate extracted | 1 study · 195 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Major adverse events Whole gland primary cryotherapy vs external beam radiotherapy (EBRT) | RR 0.91 [0.47, 1.78] | 2 studies · 293 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Time to death from any cause (absolute effects: overall mortality) Whole gland primary cryotherapy vs external beam radiotherapy (EBRT) | HR 0.99 [0.05, 18.79] | 2 studies · 293 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Secondary interventions for treatment failure ‐ not reported Whole gland primary cryotherapy vs external beam radiotherapy (EBRT) | no estimate extracted | NR | No studies |