Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

51 questions · 60 findings · 21 reviews · Gynaecology and Fertility

No studies found 4 · 6.7%GRADE not reported 4 · 6.7%Very low 19 · 31.7%Low 22 · 36.7%Moderate 7 · 11.7%High 4 · 6.7%

Summary of findings table ‐ Progestogens vs GnRH agonist

Live birth or ongoing pregnancy · assisted reproduction technology cycles

Summary of findings table ‐ Progestagen showed no clear difference in live birth or ongoing pregnancy compared with gnRH agonist (low certainty).

1 finding from 1 review

Embryo culture supernatant injection vs no intervention

Live birth or ongoing pregnancy · Subfertile women undergoing assisted reproduction

It is very uncertain whether embryo culture supernatant injection changes live birth/ongoing pregnancy compared with no intervention (very low certainty).

1 finding from 1 review

GM‐CSF‐supplemented culture media vs culture media not supplemented with GM‐CSF

Live birth or ongoing pregnancy · women undergoing assisted reproduction

GM‐CSF‐supplemented culture media showed no clear difference in live birth or ongoing pregnancy compared with culture media not supplemented with GM‐CSF (low certainty).

1 finding from 1 review

TLS with conventional morphological assessment of still TLS images vs conventional incubation and assessment

Live birth or ongoing pregnancy · couples undergoing assisted reproductive technology

TLS with conventional morphological assessment of still TLS images showed no clear difference in live birth or ongoing pregnancy compared with conventional incubation and assessment (low certainty).

1 finding from 1 review

TLS utilising embryo selection software vs TLS with conventional morphological assessment of still TLS images

Live birth or ongoing pregnancy · couples undergoing assisted reproductive technology

It is very uncertain whether TLS utilising embryo selection software changes live birth or ongoing pregnancy compared with TLS with conventional morphological assessment of still TLS images (very low certainty).

1 finding from 1 review

TLS utilising embryo selection software vs conventional incubation and assessment

Live birth or ongoing pregnancy · couples undergoing ART

It is very uncertain whether TLS utilising embryo selection software changes live birth or ongoing pregnancy compared with conventional incubation and assessment (very low certainty).

1 finding from 1 review

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

Live birth or ongoing pregnancy · Women undergoing ART (IVF, ICSI, or frozen embryo transfer)

ART with seminal plasma showed no clear difference in live birth or ongoing pregnancy compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

1 finding from 1 review

Intrauterine infusion of autologous platelet‐rich plasma vs intrauterine infusion of granulocyte colony‐stimulating factor

Live birth or ongoing pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion of autologous platelet‐rich plasma changes live birth (or ongoing pregnancy compared with intrauterine infusion of granulocyte colony‐stimulating factor (very low certainty).

1 finding from 1 review

Intrauterine infusion of autologous platelet‐rich plasma vs no intervention

Live birth or ongoing pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine injection of autologous platelet‐rich plasma changes live birth (or ongoing pregnancy) compared with no intervention (very low certainty).

1 finding from 1 review

Intrauterine infusion/injection of autologous platelet‐rich plasma vs placebo or no intervention

Live birth or ongoing pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion/injection of autologous platelet‐rich plasma changes live birth (or ongoing pregnancy) compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Progesterone vs no treatment or placebo (route of progesterone administration)

Live birth or ongoing pregnancy · women trying to conceive by intrauterine insemination

Progesterone showed no clear difference in live birth/ongoing pregnancy rate compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review