Cochrane · systematic review · CD011320
Time‐lapse systems for embryo incubation and assessment in assisted reproduction
Armstrong, S, Bhide, P, Jordan, V, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
10
No studies
1
Included studies
NR
No studies 1 · 8.3%Ungraded 1 · 8.3%Very low 6 · 50%Low 4 · 33.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsTLS with conventional morphological assessment of still TLS images compared to conventional incubation and assessment for embryo incubation and assessment in assisted reproduction
Population: couples undergoing assisted reproductive technology
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth or ongoing pregnancy TLS with conventional morphological assessment of still TLS images vs conventional incubation and assessment | OR 0.91 [0.67, 1.23] | 3 studies · 826 participants | Low Downgraded: risk of bias, imprecision |
Miscarriage TLS with conventional morphological assessment of still TLS images vs conventional incubation and assessment | OR 1.9 [0.99, 3.61] | 3 studies · 826 participants | Low Downgraded: risk of bias, imprecision |
Stillbirth TLS with conventional morphological assessment of still TLS images vs conventional incubation and assessment | OR 1 [0.13, 7.49] | 1 study · 76 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancy TLS with conventional morphological assessment of still TLS images vs conventional incubation and assessment | OR 1.06 [0.79, 1.41] | 4 studies · 875 participants | Low Downgraded: risk of bias, imprecision |
TLS utilising embryo selection software compared to TLS with conventional morphological assessment of still TLS images for embryo incubation and assessment in assisted reproduction
Population: couples undergoing assisted reproductive technology
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth or ongoing pregnancy TLS utilising embryo selection software vs TLS with conventional morphological assessment of still TLS images | OR 0.61 [0.32, 1.2] | 1 study · 163 participants | Very low Downgraded: risk of bias, imprecision |
Miscarriage TLS utilising embryo selection software vs TLS with conventional morphological assessment of still TLS images | OR 1.39 [0.64, 3.01] | 2 studies · 463 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Stillbirth TLS utilising embryo selection software vs TLS with conventional morphological assessment of still TLS images | no estimate extracted | NR | No studies |
Clinical pregnancy TLS utilising embryo selection software vs TLS with conventional morphological assessment of still TLS images | OR 0.97 [0.67, 1.42] | 2 studies · 463 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
TLS utilising embryo selection software compared to conventional incubation and assessment for embryo incubation and assessment in assisted reproduction
Population: couples undergoing ART
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth or ongoing pregnancy TLS utilising embryo selection software vs conventional incubation and assessment | OR 1.12 [0.92, 1.36] | 3 studies · 1617 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Miscarriage TLS utilising embryo selection software vs conventional incubation and assessment | OR 0.63 [0.45, 0.89] | 3 studies · 1617 participants | Very low Downgraded: risk of bias, indirectness |
Stillbirth TLS utilising embryo selection software vs conventional incubation and assessment | no estimate extracted | 1 study · 600 participants | Ungraded |
Clinical pregnancy TLS utilising embryo selection software vs conventional incubation and assessment | OR 0.95 [0.78, 1.16] | 3 studies · 1617 participants | Very low Downgraded: risk of bias, inconsistency, indirectness |