Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Bortezomib vs no bortezomib

Adverse Events: Peripheral Neuropathy ‐ Bortezomib versus no bortezomib (same background therapy) · All patients with a diagnosis of multiple myeloma

Bortezomib may leads to higher adverse Events: Peripheral Neuropathy ‐ Bortezomib versus no… compared with no bortezomib (low certainty).

1 finding from 1 review

Psychological therapy vs usual care or attention control

Adverse events: all ‐ central nervous system events (e.g. suicidal intentions) (secondary outcome) · people with depression after stroke

It is very uncertain whether psychological therapy changes adverse events: all ‐ central nervous system events (e.g. suicidal… compared with usual care and/or attention control (very low certainty).

1 finding from 1 review

Cycled inhaled tobramycin vs culture‐based TNS

Adverse effects of antibiotics: proportion of participants with one or more serious adverse event · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Cycled inhaled tobramycin (TNS) probably leads to lower adverse effects of antibiotics: proportion of participants with one… compared with culture‐based TNS (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse effect/event: clinically important extrapyramidal adverse events ‐ akathisia (medium term) · patients with schizophrenia

The intervention showed no clear difference in adverse effect/event: clinically important extrapyramidal adverse… (low certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Participants with adverse events ‐ potential immune‐mediated disease Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine showed no clear difference in participants with adverse events ‐ potential immune‐mediated… compared with placebo (moderate certainty).

1 finding from 1 review

Alemtuzumab 24 mg vs interferon beta‐1a

Adverse events, including serious adverse events Assessed by: number of participants with ≥ 1 event · adults with multiple sclerosis Interventions: immunosuppressive and immunomodulatory drugs Comparator: placebo Outcome: withdrawals due to…

Alemtuzumab 24 mg showed no clear difference in adverse events, including serious adverse events Assessed by: number… compared with interferon beta‐1a (low certainty).

1 finding from 1 review

Any preprocedural mouth rinse vs Placebo, no rinsing or control

Adverse events such as transient discolouration, altered taste, allergic reaction, hypersensitivity · People undergoing aerosol-generating procedures (AGPs) in a dental setting

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events (Re‐operation for bleeding (reoperation for major bleeding within 30 days (yes/no))) · adults undergoing surgery

It is very uncertain whether the intervention changes adverse events (Re‐operation for bleeding (reoperation for major… (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs salicylic acid

Adverse effect/event: 2. Adverse effects ‐ any ‐ medium‐termonly · participants with acne

It is very uncertain whether benzoyl peroxide changes total number of participants with any adverse events (medium‐term… compared with salicylic acid (very low certainty).

1 finding from 1 review

Radix Sophorae flavescentis vs placebo or no intervention

Non‐serious adverse events Maximum · chronic hepatitis B

It is very uncertain whether radix Sophorae flavescentis changes proportion of participants with 1 or more adverse events considered… compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Acupuncture vs no intervention

Non‐serious adverse events Maximum · chronic hepatitis B

It is very uncertain whether acupuncture changes proportion of participants with 1 or more adverse events considered… compared with no intervention (very low certainty).

1 finding from 1 review

Intervention not reported

Secondary outcome 6: adverse events (gastrointestinal symptoms) during active treatment Duration of · male and female patients 0 to 55 years of age with physician‐diagnosed eczema

The intervention showed no clear difference in secondary outcome 6: adverse events (gastrointestinal symptoms)… (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events 1 mg morphine vs 4 mg/5 mg morphinePercentage of participants with any adverse event · patients undergoing knee arthroscopy

The review found no eligible studies for this question.

1 finding from 1 review

Sclerotherapy vs no intervention

Serious adverse events and liver‐related morbidity: incidence of congestive hypertensive gastropathy · primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis

It is very uncertain whether sclerotherapy changes serious adverse events and liver‐related morbidity: incidence of… compared with no intervention (very low certainty).

1 finding from 1 review