Cochrane · systematic review · CD012307

Exercise training for adult lung transplant recipients

Gutierrez-Arias, R, Martinez-Zapata, MJ, Gaete-Mahn, MC, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library

Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
20
No studies
8
Included studies
NR
No studies 8 · 28.6%Ungraded 0 · 0%Very low 20 · 71.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Resistance (anaerobic) exercise training versus usual care or no exercise training

Population: adult lung transplant recipients
7 questions
OutcomeEffectEvidenceStatus / GRADE
Maximal and functional exercise capacity
Resistance (anaerobic) exercise training vs usual care or no exercise training
no estimate extractedNRNo studies
HRQoL
Resistance (anaerobic) exercise training vs usual care or no exercise training
no estimate extractedNRNo studies
Adverse eventsAssessed rejection episodes of lung transplant
Resistance (anaerobic) exercise training vs usual care or no exercise training
no estimate extracted2 studies · 32 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency, indirectness
Pulmonary function
Resistance (anaerobic) exercise training vs usual care or no exercise training
no estimate extractedNRNo studies
Muscular strength1 Assessed lumbar strength at seven testing positions
Resistance (anaerobic) exercise training vs usual care or no exercise training
no estimate extracted2 studies · 32 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency, indirectness
Pathological bone fractures Estimated indirectly through BMD
Resistance (anaerobic) exercise training vs usual care or no exercise training
no estimate extracted2 studies · 32 participantsVery low
Downgraded: risk of bias, imprecision, inconsistency, indirectness
Death (any cause)
Resistance (anaerobic) exercise training vs usual care or no exercise training
no estimate extractedNRNo studies

Resistance (anaerobic) exercise training versus another form of resistance (anaerobic) exercise training

Population: adult lung transplant recipients
7 questions
OutcomeEffectEvidenceStatus / GRADE
Maximal and functional exercise capacity Assessed metres walked in 6MWT
Resistance (anaerobic) exercise training vs another form of resistance (anaerobic) exercise training
no estimate extracted3 studies · 214 participantsVery low
Downgraded: risk of bias, imprecision
HRQoL Assessed by different questionnaires (CRQ and SF‐36)
Resistance (anaerobic) exercise training vs another form of resistance (anaerobic) exercise training
no estimate extracted3 studies · 215 participantsVery low
Downgraded: risk of bias, imprecision, indirectness
Adverse events Assessed indirectly related to the exercise
Resistance (anaerobic) exercise training vs another form of resistance (anaerobic) exercise training
no estimate extracted2 studies · 162 participantsVery low
Downgraded: risk of bias, imprecision, indirectness
Pulmonary function
Resistance (anaerobic) exercise training vs another form of resistance (anaerobic) exercise training
no estimate extractedNRNo studies
Muscular strength Assessed upper and lower limb muscle strength
Resistance (anaerobic) exercise training vs another form of resistance (anaerobic) exercise training
no estimate extracted3 studies · 245 participantsVery low
Downgraded: risk of bias, imprecision, indirectness
Pathological bone fractures
Resistance (anaerobic) exercise training vs another form of resistance (anaerobic) exercise training
no estimate extractedNRNo studies
Death (any cause)
Resistance (anaerobic) exercise training vs another form of resistance (anaerobic) exercise training
no estimate extracted1 study · 83 participantsVery low
Downgraded: risk of bias, imprecision, indirectness

Multimodal exercise training versus usual care or no exercise training

Population: adult lung transplant recipients
7 questions
OutcomeEffectEvidenceStatus / GRADE
Maximal and functional exercise capacity
Multimodal exercise training vs usual care or no exercise training
no estimate extracted2 studies · 80 participantsVery low
Downgraded: risk of bias, imprecision
HRQoL Assessed by different domains of the SF‐36 questionnaire
Multimodal exercise training vs usual care or no exercise training
no estimate extracted2 studies · 80 participantsVery low
Downgraded: risk of bias, imprecision
Adverse events Assessed the severe medical complications and exercise‐related musculoskeletal pain
Multimodal exercise training vs usual care or no exercise training
no estimate extracted2 studies · 80 participantsVery low
Downgraded: risk of bias, imprecision, indirectness
Pulmonary function Assessed by FEV1 (absolute value and percentage of predicted value)
Multimodal exercise training vs usual care or no exercise training
no estimate extracted2 studies · 80 participantsVery low
Downgraded: risk of bias, imprecision, indirectness
Muscular strength Assessed hand grip, upper and lower limb muscle strength
Multimodal exercise training vs usual care or no exercise training
no estimate extracted2 studies · 80 participantsVery low
Downgraded: risk of bias, imprecision, indirectness
Pathological bone fractures
Multimodal exercise training vs usual care or no exercise training
no estimate extractedNRNo studies
Death (any cause)
Multimodal exercise training vs usual care or no exercise training
no estimate extracted1 study · 40 participantsVery low
Downgraded: risk of bias, imprecision, indirectness

Fourteen‐weeks versus 7‐weeks multimodal exercise training

Population: adult lung transplant recipients
7 questions
OutcomeEffectEvidenceStatus / GRADE
Maximal and functional exercise capacity Assessed metres walked in 6MWT
Fourteen‐weeks vs 7‐weeks multimodal exercise training
no estimate extracted1 study · 61 participantsVery low
Downgraded: risk of bias, imprecision
HRQoL Assessed by different questionnaires (SF‐36 and AQoL)
Fourteen‐weeks vs 7‐weeks multimodal exercise training
no estimate extracted1 study · 59 participantsVery low
Downgraded: risk of bias, imprecision
Adverse events
Fourteen‐weeks vs 7‐weeks multimodal exercise training
no estimate extracted1 study · 66 participantsVery low
Downgraded: risk of bias, imprecision
Pulmonary function Assessed by FEV1 and FVC
Fourteen‐weeks vs 7‐weeks multimodal exercise training
no estimate extracted1 study · 66 participantsVery low
Downgraded: risk of bias, imprecision
Muscular strength Assessed by peak quadriceps muscle strength
Fourteen‐weeks vs 7‐weeks multimodal exercise training
no estimate extracted1 study · 59 participantsVery low
Downgraded: risk of bias, imprecision
Pathological bone fractures
Fourteen‐weeks vs 7‐weeks multimodal exercise training
no estimate extractedNRNo studies
Death (any cause)
Fourteen‐weeks vs 7‐weeks multimodal exercise training
no estimate extracted1 study · 66 participantsVery low
Downgraded: risk of bias, imprecision