Cochrane · systematic review · CD011027
Oral dextrose gel for the treatment of hypoglycaemia in newborn infants
Edwards, T, Liu, G, Battin, M, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 2 · 33.3%Moderate 3 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsOral dextrose gel versus control
Population: newborn infants with hypoglycaemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Correction of hypoglycaemia for each hypoglycaemic event before discharge home (investigator defined) Oral dextrose gel vs control | Rate ratio 1.08 [0.98, 1.2] | 1 study · 237 participants | Moderate Downgraded: imprecision |
Major neurological disability at age 2 years or olderb Defined as any of the following: legal blindness, sensorineural deafness requiring hearing aids, moderate or severe cerebral palsy, developmental delay/intellectual impairment (defined as deve... Oral dextrose gel vs control | RR 0.46 [0.09, 2.47] | 1 study · 185 participants | Low Downgraded: imprecision |
Receipt of intravenous treatment for hypoglycaemia before discharge home (for each infant) (yes/no) Oral dextrose gel vs control | RR 0.78 [0.46, 1.32] | 2 studies · 312 participants | Very low Downgraded: imprecision, inconsistency |
Adverse events (e.g. choking or vomiting at time of administration) before discharge home (yes/no) Oral dextrose gel vs control | no estimate extracted | 1 study · 237 participants | Low Downgraded: imprecision |
Separation from mother for treatment of hypoglycaemia before discharge home (infant nursed in an environment that is not in the same room as the mother, e.g. for NICU admission or the like) Oral dextrose gel vs control | RR 0.54 [0.31, 0.93] | 1 study · 237 participants | Moderate Downgraded: imprecision |
Exclusive breastfeeding after discharge (WHO 2008 definition (yes/no)) Oral dextrose gel vs control | RR 1.1 [1.01, 1.18] | 1 study · 237 participants | Moderate Downgraded: imprecision |