Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Apatinib plus chemotherapy or chemotherapy/brachytherapy vs chemotherapy or chemotherapy/brachytherapy

Specific adverse events: gastrointestinal perforations or fistulae ‐ not reported · women with recurrent or FIGO stage IVB cervical cancer

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

MST vs ECT ‐ adverse events that led to discontinuation of treatment (short term) · patients with schizophrenia
1 finding from 1 review

Alarm vs other types of alarm

Proportion of children with adverse events ‐ code‐word alarm versus control alarm · children with nocturnal enuresis

Alarm showed no clear difference in proportion of children with adverse events ‐ code‐word alarm versus… compared with other types of alarm (moderate certainty).

1 finding from 1 review

Neonatal vitamin A supplementation vs control

Adverse events during first 48‐72 hours post supplementation ‐ bulging fontanelle · mortality and morbidity in term neonates

Neonatal vitamin A supplementation leads to higher adverse events during first 48‐72 hours post supplementation ‐… compared with control (high certainty).

1 finding from 1 review

Active cancer therapy combined with TCM vs active cancer therapy

Adverse events ‐ renal and hepatic impairment‐ Xiaoaiping Diagnosed by clinicians · patients with oesophageal cancer

Active cancer therapy combined with TCM showed no clear difference in adverse events ‐ renal and hepatic impairment‐ Xiaoaiping Diagnosed… compared with active cancer therapy (low certainty).

1 finding from 1 review

Tranexamic acid vs placebo (saline solution or sterile water)

Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty).

1 finding from 1 review

Pharmacological interventions vs pharmacological intervention

Adverse events ‐ Metformin plus liraglutide vs metformin Nausea Diarrhoea Headache · obese women with subfertility

It is very uncertain whether pharmacological intervention changes adverse events ‐ Metformin plus liraglutide vs metformin Nausea… compared with pharmacological intervention (very low certainty).

1 finding from 1 review

Vitamin D plus calcium vs vitamin D

Adverse events (number) Asymptomatic hypercalcaemia and hypercalciuria

It is very uncertain whether vitamin D plus calcium changes adverse events (number) Definition: asymptomatic hypercalcaemia and… compared with vitamin D (very low certainty).

1 finding from 1 review

Valproate vs placebo

Adverse effects: 1. Sedation · Adults (aged 18 and over) with acute mania

Valproate showed no clear difference in individual adverse events ‐ Sedation At 3‐8 weeks (secondary… compared with placebo (high certainty).

1 finding from 1 review