Cochrane · systematic review · CD012581
Vitamin D, calcium or a combination of vitamin D and calcium for the treatment of nutritional rickets in children
Chibuzor, MT, Graham‐Kalio, D, Osaji, JO, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Metabolic and Endocrine DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
8
No studies
10
Included studies
NR
No studies 10 · 47.6%Ungraded 3 · 14.3%Very low 6 · 28.6%Low 2 · 9.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Vitamin D or calcium for the treatment of nutritional rickets in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Healing of rickets (number) Definition: normal alkaline phosphatase and bone radiograph | RR 3.26 [1.59, 6.69] | 1 study · 71 participants | Low Downgraded: imprecision |
Morbidity (number) Definition: fractures | RR 0.27 [0.03, 2.32] | 1 study · 71 participants | Very low Downgraded: imprecision |
Adverse events (number) | no estimate extracted | NR | No studies |
All‐cause mortality | no estimate extracted | NR | No studies |
Health‐related quality of life | no estimate extracted | NR | No studies |
Growth pattern | no estimate extracted | 1 participants | Ungraded |
Socioeconomic effects | no estimate extracted | NR | No studies |
Vitamin D plus calcium versus vitamin D for the treatment of nutritional rickets in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Healing of rickets (number) Definition: normal alkaline phosphatase and bone radiograph Vitamin D plus calcium vs vitamin D | RR 3.06 [1.49, 6.29] | 1 study · 75 participants | Low Downgraded: imprecision |
Morbidity (number) Definition: fractures Vitamin D plus calcium vs vitamin D | RR 0.24 [0.03, 2.08] | 1 study · 75 participants | Very low Downgraded: imprecision |
Adverse events (number) Definition: asymptomatic hypercalcaemia and hypercalciuria Vitamin D plus calcium vs vitamin D | RR 4.76 [0.24, 93.19] | 1 study · 39 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality Vitamin D plus calcium vs vitamin D | no estimate extracted | NR | No studies |
Health‐related quality of life Vitamin D plus calcium vs vitamin D | no estimate extracted | NR | No studies |
Growth pattern Vitamin D plus calcium vs vitamin D | no estimate extracted | 1 participants | Ungraded |
Socioeconomic effects Vitamin D plus calcium vs vitamin D | no estimate extracted | NR | No studies |
Vitamin D plus calcium versus calcium for the treatment of nutritional rickets in children
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Healing of rickets (number) Definition: normal alkaline phosphatase and bone radiograph Vitamin D plus calcium vs calcium | RR 1.17 [0.72, 1.9] | 2 studies · 140 participants | Very low Downgraded: risk of bias, imprecision |
Morbidity (number) Definition: fractures Vitamin D plus calcium vs calcium | RR 0.89 [0.06, 13.76] | 1 study · 72 participants | Very low Downgraded: imprecision |
Adverse events (number) Asymptomatic hypercalcaemia and hypercalciuria Vitamin D plus calcium vs calcium | RR 4.29 [0.22, 83.57] | 1 study · 37 participants | Very low Downgraded: risk of bias, imprecision |
All‐cause mortality Vitamin D plus calcium vs calcium | no estimate extracted | NR | No studies |
Health‐related quality of life Vitamin D plus calcium vs calcium | no estimate extracted | NR | No studies |
Growth pattern Vitamin D plus calcium vs calcium | no estimate extracted | 1 participants | Ungraded |
Socioeconomic effects Vitamin D plus calcium vs calcium | no estimate extracted | NR | No studies |