Question · asked by 1 review
Tranexamic acid vs placebo (saline solution or sterile water): Significant adverse events (seizures, thromboembolism) within 24 hours of surgery)
- Population
- adults and children with chronic rhinosinusitis with or without nasal polyps
- Intervention
- Tranexamic acid
- Comparison
- placebo (saline solution or sterile water)
- Outcome
- Significant adverse events (seizures, thromboembolism) within 24 hours of surgery)
Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Tranexamic acid vs placebo (saline solution or sterile water) Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty). Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery (2023) · Cochrane Headline outcomes only | RD 0 | 8 studies · 664 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.