Cochrane · systematic review · CD012843
Tranexamic acid for the reduction of bleeding during functional endoscopic sinus surgery
Lourijsen, E, Avdeeva, K, Gan, KL, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 5 · 71.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Tranexamic acid versus placebo (saline solution or sterile water) for the reduction of bleeding during functional endoscopic sinus surgery
Population: adults and children with chronic rhinosinusitis with or without nasal polyps
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Surgical field bleeding score (during surgery or < 30 minutes after surgery) Tranexamic acid vs placebo (saline solution or sterile water) | no estimate extracted | 13 studies · 772 participants | Moderate Downgraded: inconsistency |
Intraoperative blood loss Assessed as: total amount of blood loss during surgery in mL Tranexamic acid vs placebo (saline solution or sterile water) | no estimate extracted | 12 studies · 802 participants | Low Downgraded: imprecision, inconsistency, indirectness |
Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) Tranexamic acid vs placebo (saline solution or sterile water) | RD 0 | 8 studies · 664 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Duration of surgery (minutes) Assessed as: total surgical time Tranexamic acid vs placebo (saline solution or sterile water) | no estimate extracted | 10 studies · 666 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Incomplete surgery Tranexamic acid vs placebo (saline solution or sterile water) | RD 0 | 2 studies · 58 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Surgical complications Tranexamic acid vs placebo (saline solution or sterile water) | RD 0 | 2 studies · 58 participants | Moderate Downgraded: imprecision, inconsistency, indirectness |
Postoperative bleeding (place of packing or revision surgery within 14 days of surgery) Tranexamic acid vs placebo (saline solution or sterile water) | no estimate extracted | 6 studies · 404 participants | Low Downgraded: imprecision, inconsistency, indirectness |