Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Topical antibiotics with steroids vs topical steroid

Minor adverse events not leading to withdrawal of treatment · people with eczema

It is very uncertain whether topical steroid plus topical antibiotic changes minor adverse events not requiring withdrawal from treatment compared with topical steroid (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events: any adverse events requiring hospitalisation · people with primary delusional infestation
1 finding from 1 review

Hysterectomy with opportunistic salpingectomy vs hysterectomy without opportunistic salpingectomy

Surgery‐related adverse events: intraoperative complications · premenopausal women undergoing hysterectomy for benign gynaecological indications

It is very uncertain whether hysterectomy with opportunistic salpingectomy changes surgery‐related adverse events: intraoperative complications compared with hysterectomy without opportunistic salpingectomy (very low certainty).

1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs usual care

Adverse events: Clinically important specific adverse events · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Adverse events: Clinically important specific adverse events · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Motivational interview plus oral health education vs Oral health education

Adverse events: Clinically important specific adverse events · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Serious Adverse Events (Participants with one or more event) · Adults (>18 years) with pulmonary hypertension of varied aetiology (PAH, CTEPH and left heart disease)

It is very uncertain whether the intervention changes serious Adverse Events (Participants with one or more event) (very low certainty).

1 finding from 1 review

TDC vs medical therapy

Secondary outcome:total serious adverse events at the end of · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in secondary outcome:total serious adverse events at the end of compared with medical therapy (low certainty).

1 finding from 1 review

Nicotine EC vs non‐nicotine EC

Adverse events at 1 week to 6 months Assessed via self‐report · People who smoke cigarettes

Nicotine EC showed no clear difference in adverse events at 1 week to 6 months Assessed via self‐report compared with non‐nicotine EC (moderate certainty).

1 finding from 1 review

Antibiotic prophylaxis before dental procedure vs placebo or no prophylaxis

Mortality or serious adverse events requiring hospital admission · Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive dental procedure

The review found no eligible studies for this question.

1 finding from 1 review

Brivaracetam vs placebo

Adverse events as N of participants with at least one adverse event objective · people with drug‐resistant focal epilepsy

Brivaracetam showed no clear difference in proportion of participants who experienced any adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Adverse events RR < 1 indicates lower risk of adverse events · adults with common mental disorders

Lay health worker‐led psychological interventions may leads to lower adverse events RR < 1 indicates lower risk of adverse events compared with usual care (low certainty).

1 finding from 1 review