Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Nonavalent HPV vaccine vs quadrivalent HPV vaccine

Overall local/injection site adverse events at 15‐day · 9‐ to 26‐year‐old females and males

Nonavalent HPV vaccine leads to higher overall local/injection site adverse events at 15‐day compared with quadrivalent HPV vaccine (high certainty).

1 finding from 1 review

Intervention not reported

Adverse events leading to treatment discontinuation ( · adults and adolescents with pleural TB

The intervention may leads to higher adverse events leading to treatment discontinuation ( (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (number of adverse events/person/year) · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

The intervention showed no clear difference in adverse events (number of adverse events/person/year) (low certainty).

1 finding from 1 review

Oestrogen in combination with progestogen (sequential or continuous) vs placebo

Specific adverse events · women with PMS

It is very uncertain whether oestrogen in combination with progestogen (sequential or continuous) changes specific adverse events over 2 to 4 menstrual cycles1 compared with placebo (very low certainty).

1 finding from 1 review

Umeclidinium bromide vs placebo

Adverse events (not including serious adverse events): number of participants · patients with chronic obstructive pulmonary disease

Umeclidinium bromide showed no clear difference in adverse events (not including serious adverse events) compared with placebo (moderate certainty).

1 finding from 1 review

Supervised dosing with a long‐acting medication vs unsupervised consumption

Adverse serious events (any) (number of participants) · patients with opioid dependence

It is very uncertain whether supervised dosing with a long‐acting medication changes adverse serious events (any) (number of participants) compared with unsupervised consumption (very low certainty).

1 finding from 1 review

SSRIs or SNRIs vs amitriptyline

Participants who withdraw because of an adverse event or any other reason · patients for whom migraine preventive interventions are indicated

SSRIs or SNRIs showed no clear difference in withdrawn (for any reasons and due to adverse events) compared with amitriptyline (low certainty).

1 finding from 1 review

PERPHENAZINE vs placebo

Adverse events: serious adverse events ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Lidocaine vs disopyramide

Adverse events (AEs; adverse drug reaction): asystole · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): asystole compared with disopyramide (very low certainty).

1 finding from 1 review

Lidocaine vs placebo or no intervention

Adverse events (AEs; adverse drug reaction): asystole · patients with acute myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): asystole compared with placebo or no intervention (very low certainty).

1 finding from 1 review