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The review found no eligible studies for this question.
Black staining of arrested lesions was the main adverse event of SDF (reported by seven reviews); it was generally acceptable to patients (ungraded).
It is very uncertain whether topical steroid plus topical antibiotic changes adverse events requiring withdrawal from treatment compared with topical steroid (very low certainty).
Oral immunosuppressants: oral cyclosporin showed no clear difference in primary: adverse events ‐ at least 1 adverse event compared with topical betamethasone dipropionate (moderate certainty).
Corticosteroid creams/ointments: clobetasol propionate foam showed no clear difference in primary: adverse events ‐ at least 1 adverse event compared with vehicle foam (moderate certainty).
Routine preoperative medical testing showed no clear difference in ocular adverse events up to 2 months after surgery compared with selective or no testing (moderate certainty).
Paracetamol showed no clear difference in total adverse events: number experiencing 24 weeks compared with placebo (high certainty).
The review found no eligible studies for this question.
It is very uncertain whether oral + inhaled dual therapy changes serious adverse events. Outcome assessed on day 42 compared with oral monotherapy (very low certainty).
Alemtuzumab 24 mg showed no clear difference in number of participants with serious adverse events compared with interferon beta 1a (moderate certainty).
Alemtuzumab 12 mg showed no clear difference in number of participants with serious adverse events compared with interferon beta 1a (moderate certainty).
Partial nephrectomy showed no clear difference in serious adverse events (Surgery‐related mortality) compared with radical nephrectomy (low certainty).
RISPERIDONE DEPOT showed no clear difference in adverse events: General ‐ serious Recorded at each compared with ORAL QUETIAPINE (low certainty).
The intervention showed no clear difference in severe adverse events: raised alkaline phosphatase (low certainty).
Active cancer therapy combined with TCM showed no clear difference in adverse events ‐ mucositis Diagnosed by clinicians compared with active cancer therapy (low certainty).
Any antiglucocorticoid probably leads to higher adverse effects: 1. General ‐ overall number of events compared with placebo (moderate certainty).
The intervention showed no clear difference in adverse events ‐ serious systemic events at 1 year (moderate certainty).