Cochrane · systematic review · CD012514
Dual antibiotics for bronchiectasis
Felix, LM, Grundy, S, Milan, SJ, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 3 · 37.5%Very low 5 · 62.5%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Oral + inhaled dual therapy compared with oral monotherapy for bronchiectasis
Population: bronchiectasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Successful treatment of exacerbation: number of participants cured. Outcome assessed on day 42 Oral + inhaled dual therapy vs oral monotherapy | OR 0.66 [0.22, 2.01] | 1 study · 53 participants | Very low Downgraded: risk of bias |
Successful treatment of exacerbation: number of participants with P aeruginosa eradication. Outcome assessed on day 21 Oral + inhaled dual therapy vs oral monotherapy | OR 2.33 [0.66, 8.24] | 1 study · 53 participants | Very low Downgraded: risk of bias |
Serious adverse events. Outcome assessed on day 42 Oral + inhaled dual therapy vs oral monotherapy | OR 0.48 [0.08, 2.87] | 1 study · 53 participants | Very low Downgraded: risk of bias |
Treatment response: relapse (day 42). Outcome assessed on day 42 Oral + inhaled dual therapy vs oral monotherapy | OR 0.57 [0.12, 2.69] | 1 study · 53 participants | Very low Downgraded: risk of bias |
Microbiological response: eradicated. Outcome assessed on day 21 Oral + inhaled dual therapy vs oral monotherapy | OR 2.4 [0.67, 8.65] | 1 study · 49 participants | Very low Downgraded: risk of bias |
Hospitalisations Oral + inhaled dual therapy vs oral monotherapy | no estimate extracted | 0 studies · 0 participants | Ungraded |
Death Oral + inhaled dual therapy vs oral monotherapy | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of life Oral + inhaled dual therapy vs oral monotherapy | no estimate extracted | 0 studies · 0 participants | Ungraded |