Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

1,949 questions · 1,994 findings · 636 reviews

No studies found 504 · 25.3%GRADE not reported 340 · 17.1%Very low 477 · 23.9%Low 390 · 19.6%Moderate 241 · 12.1%High 42 · 2.1%

Intervention not reported

Gastrointestinal adverse effects (increased abdominal pain, nausea, vomiting). · Adults 18 yrs and over with malignant bowel obstruction (MBO) as defined by the International Conference on MBO, with no indication for…
1 finding from 1 review

NIDOTHERAPY‐ENHANCED STANDARD CARE vs usual care

Adverse effect: Specific ‐ Death · schizophrenia

It is very uncertain whether NIDOTHERAPY‐ENHANCED STANDARD CARE changes adverse effects ‐ specific ‐ death Number of individual deaths of… compared with STANDARD CARE (very low certainty).

1 finding from 1 review

VIDEO GAMES (COMMERCIAL NON‐EXERGAMES) (plus standard care) vs COGNITIVE REMEDIATION (plus standard care)

Adverse effects*: leaving the study early ‐ did not leave · patients with schizophrenia

VIDEO GAMES (COMMERCIAL NON‐EXERGAMES) (plus standard care) showed no clear difference in adverse effects*: leaving the study early ‐ did not leave ‐ by end… compared with COGNITIVE REMEDIATION (plus standard care) (low certainty).

1 finding from 1 review

HALOPERIDOL vs ZIPRASIDONE

Adverse effects: Specific ‐ clinically significant abnormal ECG during 72 hours · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ clinically significant abnormal ECG… compared with OTHER ANTIPSYCHOTIC: j. ZIPRASIDONE (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs erythromycin

Withdrawals due to adverse outcomes · participants with acne

It is very uncertain whether benzoyl peroxide changes withdrawal due to adverse effects (medium‐term data) Treatment… compared with erythromycin (very low certainty).

1 finding from 1 review

Secukinumab vs placebo

Proportion of participants with adverse effects in the short term ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Extended specialised early intervention (SEI) teams vs standard SEI teams plus treatment

Adverse effects/events: death ‐ all‐cause mortality(assessed by patient records) · recent‐onset psychosis

Extended specialised early intervention (SEI) teams showed no clear difference in adverse effects/events: death ‐ all‐cause mortality(assessed by… compared with standard SEI teams plus treatment (low certainty).

1 finding from 1 review

Group C cognitive behavioural therapy: cognitive behavioural therapy + risperidone vs placebo or supportive treatment

Adverse effects: specific ‐ doctors' assessment of adverse effects UKU (events) Medium‐term · people in the prodromal stage of psychosis

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes adverse effects: doctors' assessment of adverse effects UKU (events)… compared with supportive therapy + placebo (very low certainty).

1 finding from 1 review

BIFEPRUNOX vs placebo

Weight gain · patients with schizophrenia

BIFEPRUNOX showed no clear difference in adverse effects: Weight ‐ Total number of participants with ≥ 7%… compared with PLACEBO (moderate certainty).

1 finding from 1 review

Videolaryngoscopy vs direct laryngoscopy

Non‐airway‐related adverse effects: desaturation or bradycardia episodes, or both · neonates (0 to 28 days of age) who needed tracheal intubation

It is very uncertain whether videolaryngoscopy changes non‐airway‐related adverse effects: desaturation or bradycardia… compared with conventional direct laryngoscopy (very low certainty).

1 finding from 1 review

Lamotrigine vs placebo

Any reported adverse effects up to 12 weeks after starting treatment (short term) · bipolar disorder

It is very uncertain whether lamotrigine changes any reported adverse effects up to 12 weeks after starting treatment… compared with placebo (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse maternal psychological effects (anxiety, depression or complicated grief) · women with a previous stillbirth of ≥ 20 weeks' gestation who are pregnant or considering a subsequent pregnancy

It is very uncertain whether the intervention changes adverse maternal psychological effects (anxiety, depression or… (very low certainty).

1 finding from 1 review

Intervention not reported

Number of participants who experienced any adverse effects related to antibiotics · Women undergoing excision of the cervical transformation zone for cervical neoplasia

It is very uncertain whether the intervention changes number of participants who experienced any adverse effects related… (very low certainty).

1 finding from 1 review

Vitamin E + vitamin C vs placebo

Any adverse effects of vitamin supplementation sufficient to stop supplementation · pregnant women

Vitamin C and vitamin E showed no clear difference in any adverse effects of vitamin supplementation sufficient to stop… compared with placebo (moderate certainty).

1 finding from 1 review

Pyridoxal 5 phosphate (vitamin B6) vs placebo

Global: Other adverse effects than tardive dyskinesia Self‐report by participants · patients with antipsychotic‐induced tardive dyskinesia

Pyridoxal 5 phosphate (vitamin B6) showed no clear difference in global: Other adverse effects than tardive dyskinesia Self‐report by… compared with placebo (low certainty).

1 finding from 1 review

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% articaine, 1:100,000 epinephrine showed no clear difference in adverse effects: pain on injection (solution deposition),… compared with 2% lidocaine, 1:100,000 epinephrine (moderate certainty).

1 finding from 1 review