Cochrane · systematic review · CD010501
Pyridoxal 5 phosphate for neuroleptic‐induced tardive dyskinesia
Adelufosi, AO, Abayomi, O, Ojo, TMF · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Pyridoxal 5 phosphate (vitamin B6) compared with Placebo for neuroleptic‐induced tardive dyskinesia
Population: patients with neuroleptic‐induced tardive dyskinesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical efficacy ‐ improvement (> 40%) in ESRS scores from baseline ESRS1 Pyridoxal 5 phosphate (vitamin B6) vs Placebo | RR 19.97 [2.87, 139.19] | 2 studies · 65 participants | Low Downgraded: risk of bias, imprecision |
Global: Other adverse effects than tardive dyskinesia Self‐report by participants Pyridoxal 5 phosphate (vitamin B6) vs Placebo | RR 3.97 [0.2, 78.59] | 2 studies · 65 participants | Low Downgraded: risk of bias, imprecision |
Global: Discontinuation of Vitamin B6 Pyridoxal 5 phosphate (vitamin B6) vs Placebo | RR 8.72 [0.51, 149.75] | 2 studies · 65 participants | Low Downgraded: risk of bias, imprecision |
Tardive dyskinesia: Deterioration in tardive dyskinesia symptoms ESRS1 Pyridoxal 5 phosphate (vitamin B6) vs Placebo | RR 0.16 [0.01, 3.14] | 2 studies · 65 participants | Low Downgraded: risk of bias, imprecision |
General mental state: Positive psychiatric symptom score PANSS5. Scale from: 7 to 49. Pyridoxal 5 phosphate (vitamin B6) vs Placebo | no estimate extracted | 1 study · 15 participants | Low Downgraded: risk of bias, imprecision |
General mental state: Negative psychiatric symptoms PANSS5. Scale from: 7 to 49. Pyridoxal 5 phosphate (vitamin B6) vs Placebo | no estimate extracted | 1 study · 15 participants | Low Downgraded: risk of bias, imprecision |