Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,949 questions · 1,994 findings · 636 reviews

No studies found 504 · 25.3%GRADE not reported 340 · 17.1%Very low 477 · 23.9%Low 390 · 19.6%Moderate 241 · 12.1%High 42 · 2.1%

Antidepressant plus antipsychotic vs placebo plus antidepressant

Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression

The review found no eligible studies for this question.

2 findings from 1 review

Intracystic bleomycin vs other types of intracystic treatment

Total number of adverse effects · cystic craniopharyngiomas in children from birth to 18 years old

It is very uncertain whether intracystic bleomycin changes total number of adverse effects compared with other types of intracystic treatment (very low certainty).

1 finding from 1 review

Antioxidants vs control intervention

Adverse effects—parallel trials · patients with chronic pancreatitis and pancreatic pain

Antioxidant probably leads to higher adverse effects—parallel trials compared with control intervention (moderate certainty).

1 finding from 1 review

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Complications (adverse effects) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate showed no clear difference in complications (adverse effects) compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review

Oral diclofenac sodium (NSAID) vs splint

Complications (adverse effects) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Diclofenac sodium (oral NSAID) showed no clear difference in complications (adverse effects) compared with occlusal splint therapy; GRADE not reported.

1 finding from 1 review