Cochrane · systematic review · CD009412
Risperidone for psychosis‐induced aggression or agitation (rapid tranquillisation)
Ostinelli, EG, Hussein, M, Ahmed, U, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
30
current version
GRADE rated
13
No studies
17
Included studies
NR
No studies 17 · 56.7%Ungraded 0 · 0%Very low 13 · 43.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
RISPERIDONE compared to OTHER ANTIPSYCHOTIC: a. HALOPERIDOL for psychosis‐induced aggression or agitation (rapid tranquillisation)
Population: psychosis‐induced aggression or agitation (rapid tranquillisation)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tranquillisation or asleep by 30 minutes ‐ not measured RISPERIDONE vs OTHER ANTIPSYCHOTIC: a. HALOPERIDOL | no estimate extracted | NR | No studies |
Repeated need for tranquillisation within 24 hours ‐ not measured RISPERIDONE vs OTHER ANTIPSYCHOTIC: a. HALOPERIDOL | no estimate extracted | NR | No studies |
Specific behaviour: agitation, up to 24 hours (PANSS‐PAS response) RISPERIDONE vs OTHER ANTIPSYCHOTIC: a. HALOPERIDOL | RR 1.04 [0.86, 1.26] | 1 study · 124 participants | Very low Downgraded: risk of bias |
Global outcome: need for additional measures RISPERIDONE vs OTHER ANTIPSYCHOTIC: a. HALOPERIDOL | RR 2 [0.43, 9.21] | 1 study · 28 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Adverse effects: up to 24 hours RISPERIDONE vs OTHER ANTIPSYCHOTIC: a. HALOPERIDOL | RR 0.94 [0.54, 1.66] | 1 study · 124 participants | Very low Downgraded: risk of bias |
Economic outcomes ‐ not measured RISPERIDONE vs OTHER ANTIPSYCHOTIC: a. HALOPERIDOL | no estimate extracted | NR | No studies |
RISPERIDONE compared to OTHER ANTIPSYCHOTIC: b. OLANZAPINE for psychosis‐induced aggression or agitation (rapid tranquillisation)
Population: psychosis‐induced aggression or agitation (rapid tranquillisation)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tranquillisation or asleep by 30 minutes ‐ not measured RISPERIDONE vs OTHER ANTIPSYCHOTIC: b. OLANZAPINE | no estimate extracted | NR | No studies |
Repeated need for tranquillisation within 24 hours ‐ not measured RISPERIDONE vs OTHER ANTIPSYCHOTIC: b. OLANZAPINE | no estimate extracted | NR | No studies |
Specific behaviour: agitation, up to 2 hours RISPERIDONE vs OTHER ANTIPSYCHOTIC: b. OLANZAPINE | no estimate extracted | 1 study · 29 participants | Very low Downgraded: risk of bias |
Global outcome: need for additional measures RISPERIDONE vs OTHER ANTIPSYCHOTIC: b. OLANZAPINE | RR 1.43 [0.39, 5.28] | 1 study · 29 participants | Very low Downgraded: risk of bias |
Adverse effects: movement disorder RISPERIDONE vs OTHER ANTIPSYCHOTIC: b. OLANZAPINE | no estimate extracted | 1 study · 29 participants | Very low Downgraded: risk of bias |
Economic outcomes ‐ not measured RISPERIDONE vs OTHER ANTIPSYCHOTIC: b. OLANZAPINE | no estimate extracted | NR | No studies |
RISPERIDONE compared to OTHER ANTIPSYCHOTIC: c. QUETIAPINE for psychosis‐induced aggression or agitation (rapid tranquillisation)
Population: psychosis‐induced aggression or agitation (rapid tranquillisation)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tranquillisation or asleep by 30 minutes ‐ not measured RISPERIDONE vs OTHER ANTIPSYCHOTIC: c. QUETIAPINE | no estimate extracted | NR | No studies |
Repeated need for tranquillisation within 24 hours ‐ not measured RISPERIDONE vs OTHER ANTIPSYCHOTIC: c. QUETIAPINE | no estimate extracted | NR | No studies |
Specific behaviour ‐ aggression, over 24 hours RISPERIDONE vs OTHER ANTIPSYCHOTIC: c. QUETIAPINE | no estimate extracted | 1 study · 40 participants | Very low Downgraded: imprecision |
Global outcome ‐ not measured RISPERIDONE vs OTHER ANTIPSYCHOTIC: c. QUETIAPINE | no estimate extracted | NR | No studies |
Adverse effects: movement disorders over 24 hours RISPERIDONE vs OTHER ANTIPSYCHOTIC: c. QUETIAPINE | RR 1.67 [0.46, 6.06] | 1 study · 40 participants | Very low Downgraded: imprecision |
Economic outcomes ‐ not measured RISPERIDONE vs OTHER ANTIPSYCHOTIC: c. QUETIAPINE | no estimate extracted | NR | No studies |
RISPERIDONE compared to COMBINATION: a. RISPERIDONE + OXCARBAZEPINE for psychosis‐induced aggression or agitation (rapid tranquillisation)
Population: psychosis‐induced aggression or agitation (rapid tranquillisation)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tranquillisation or asleep by 30 minutes ‐ not measured RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE | no estimate extracted | NR | No studies |
Repeated need for tranquillisation within 24 hours ‐ not measured RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE | no estimate extracted | NR | No studies |
Specific behaviour: agitation, over 24 hours RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE | no estimate extracted | 1 study · 68 participants | Very low Downgraded: risk of bias |
Global Outcome: average scores, over 24 hours RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE | no estimate extracted | 1 study · 68 participants | Very low Downgraded: risk of bias |
Adverse effects: movement disorders, over 24 hours RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE | RR 1.59 [0.49, 5.14] | 1 study · 68 participants | Very low Downgraded: risk of bias |
Economic outcomes ‐ not measured RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE | no estimate extracted | NR | No studies |
RISPERIDONE compared to COMBINATION: b. RISPERIDONE + VALPROIC ACID for psychosis‐induced aggression or agitation (rapid tranquillisation)
Population: psychosis‐induced aggression or agitation (rapid tranquillisation)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Tranquillisation or asleep by 30 minutes ‐ not measured RISPERIDONE vs COMBINATION: b. RISPERIDONE + VALPROIC ACID | no estimate extracted | NR | No studies |
Repeated need for tranquillisation within 24 hours ‐ not measured RISPERIDONE vs COMBINATION: b. RISPERIDONE + VALPROIC ACID | no estimate extracted | NR | No studies |
Specific behaviour ‐ aggression, over 24 hours RISPERIDONE vs COMBINATION: b. RISPERIDONE + VALPROIC ACID | no estimate extracted | 1 study · 54 participants | Very low Downgraded: imprecision |
Global outcome ‐ not measured RISPERIDONE vs COMBINATION: b. RISPERIDONE + VALPROIC ACID | no estimate extracted | NR | No studies |
Adverse effects: movement disorders, over 24 hours RISPERIDONE vs COMBINATION: b. RISPERIDONE + VALPROIC ACID | RR 0.75 [0.28, 2.03] | 2 studies · 122 participants | Very low Downgraded: imprecision, indirectness |
Economic outcomes ‐ not measured RISPERIDONE vs COMBINATION: b. RISPERIDONE + VALPROIC ACID | no estimate extracted | NR | No studies |