Cochrane · systematic review · CD004044
Pharmacological treatment for psychotic depression
Kruizinga, J, Liemburg, E, Burger, H, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
48
current version
GRADE rated
16
No studies
32
Included studies
NR
No studies 32 · 66.7%Ungraded 0 · 0%Very low 15 · 31.3%Low 1 · 2.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antidepressant compared to placebo for psychotic depression
Population: adults with psychotic depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical response of depression Antidepressant vs placebo | RR 8.4 [0.5, 142.27] | 1 study · 27 participants | Very low Downgraded: risk of bias |
Overall dropouts Antidepressant vs placebo | RR 1.24 [0.34, 4.51] | 1 study · 27 participants | Very low Downgraded: risk of bias |
Depression remission Antidepressant vs placebo | no estimate extracted | NR | No studies |
Change in depression severity from baseline Antidepressant vs placebo | no estimate extracted | NR | No studies |
Quality of life Antidepressant vs placebo | no estimate extracted | NR | No studies |
Dropouts due to adverse effects Antidepressant vs placebo | no estimate extracted | NR | No studies |
Antipsychotic compared to placebo for psychotic depression
Population: adults with psychotic depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical response of depression Antipsychotic vs placebo | RR 1.13 [0.74, 1.73] | 2 studies · 201 participants | Very low Downgraded: risk of bias |
Overall dropouts Antipsychotic vs placebo | RR 0.79 [0.57, 1.08] | 2 studies · 201 participants | Very low Downgraded: risk of bias |
Depression remission Antipsychotic vs placebo | no estimate extracted | NR | No studies |
Change in depression severity from baseline Antipsychotic vs placebo | no estimate extracted | NR | No studies |
Quality of life Antipsychotic vs placebo | no estimate extracted | NR | No studies |
Dropouts due to adverse effects Antipsychotic vs placebo | no estimate extracted | NR | No studies |
Antidepressant compared to antidepressant for psychotic depression
Population: adults with psychotic depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical response Antidepressant vs antidepressant | no estimate extracted | NR | Very low Downgraded: imprecision |
Overall dropouts Antidepressant vs antidepressant | no estimate extracted | NR | Very low Downgraded: imprecision |
Depression remission Antidepressant vs antidepressant | no estimate extracted | NR | No studies |
Change in depression severity from baseline Antidepressant vs antidepressant | no estimate extracted | NR | No studies |
Quality of life Antidepressant vs antidepressant | no estimate extracted | NR | No studies |
Dropouts due to adverse effects Antidepressant vs antidepressant | no estimate extracted | NR | No studies |
Antidepressant compared to antipsychotic for psychotic depression
Population: adults with psychotic depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical response of depression Antidepressant vs antipsychotic | RR 2.09 [0.64, 6.82] | 1 study · 36 participants | Very low Downgraded: imprecision |
Overall dropouts Antidepressant vs antipsychotic | RR 1.79 [0.18, 18.02] | 1 study · 36 participants | Very low Downgraded: imprecision |
Depression remission Antidepressant vs antipsychotic | no estimate extracted | NR | No studies |
Change in depression severity from baseline Antidepressant vs antipsychotic | no estimate extracted | NR | No studies |
Quality of life Antidepressant vs antipsychotic | no estimate extracted | NR | No studies |
Dropouts due to adverse effects Antidepressant vs antipsychotic | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic compared to placebo for psychotic depression
Population: adults with psychotic depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical response of depression Antidepressant plus antipsychotic vs placebo | RR 1.86 [1.23, 2.82] | 2 studies · 148 participants | Very low Downgraded: risk of bias |
Overall dropouts Antidepressant plus antipsychotic vs placebo | RR 0.75 [0.48, 1.18] | 2 studies · 148 participants | Very low Downgraded: risk of bias |
Depression remission Antidepressant plus antipsychotic vs placebo | no estimate extracted | NR | No studies |
Change in depression severity from baseline Antidepressant plus antipsychotic vs placebo | no estimate extracted | NR | No studies |
Quality of life Antidepressant plus antipsychotic vs placebo | no estimate extracted | NR | No studies |
Dropouts due to adverse effects Antidepressant plus antipsychotic vs placebo | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic compared to placebo plus antipsychotic for psychotic depression
Population: adults with psychotic depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical response of depression Antidepressant plus antipsychotic vs placebo plus antipsychotic | RR 1.83 [1.4, 2.38] | 4 studies · 447 participants | Low Downgraded: risk of bias |
Overall dropouts Antidepressant plus antipsychotic vs placebo plus antipsychotic | RR 0.79 [0.63, 1.01] | 4 studies · 447 participants | Very low Downgraded: risk of bias |
Depression remission Antidepressant plus antipsychotic vs placebo plus antipsychotic | no estimate extracted | NR | No studies |
Change in depression severity from baseline Antidepressant plus antipsychotic vs placebo plus antipsychotic | no estimate extracted | NR | No studies |
Quality of life Antidepressant plus antipsychotic vs placebo plus antipsychotic | no estimate extracted | NR | No studies |
Dropouts due to adverse effects Antidepressant plus antipsychotic vs placebo plus antipsychotic | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic compared to placebo plus antidepressant for psychotic depression
Population: adults with psychotic depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical response of depression Antidepressant plus antipsychotic vs placebo plus antidepressant | RR 1.42 [1.11, 1.8] | 4 studies · 245 participants | Very low Downgraded: risk of bias, imprecision |
Overall dropouts Antidepressant plus antipsychotic vs placebo plus antidepressant | RR 0.91 [0.55, 1.5] | 4 studies · 245 participants | Very low Downgraded: risk of bias, imprecision |
Depression remission Antidepressant plus antipsychotic vs placebo plus antidepressant | no estimate extracted | NR | No studies |
Change in depression severity from baseline Antidepressant plus antipsychotic vs placebo plus antidepressant | no estimate extracted | NR | No studies |
Quality of life Antidepressant plus antipsychotic vs placebo plus antidepressant | no estimate extracted | NR | No studies |
Dropouts due to adverse effects Antidepressant plus antipsychotic vs placebo plus antidepressant | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic compared to placebo plus the same antidepressant for psychotic depression
Population: adults with psychotic depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical response of depression Antidepressant plus antipsychotic vs placebo plus the same antidepressant | RR 1.7 [1.19, 2.43] | 3 studies · 157 participants | Very low Downgraded: risk of bias |
Overall dropouts Antidepressant plus antipsychotic vs placebo plus the same antidepressant | RR 1.04 [0.52, 2.07] | 3 studies · 157 participants | Very low Downgraded: risk of bias |
Depression remission Antidepressant plus antipsychotic vs placebo plus the same antidepressant | no estimate extracted | NR | No studies |
Change in depression severity from baseline Antidepressant plus antipsychotic vs placebo plus the same antidepressant | no estimate extracted | NR | No studies |
Quality of life Antidepressant plus antipsychotic vs placebo plus the same antidepressant | no estimate extracted | NR | No studies |
Dropouts due to adverse effects Antidepressant plus antipsychotic vs placebo plus the same antidepressant | no estimate extracted | NR | No studies |