Cochrane Review Group
Epilepsy
77 systematic reviews in Epilepsy ask 970 questions. 19.6% have no studies to answer them, 13.9% rest on very low certainty evidence and 32.3% reach moderate or high certainty.
Reviews
77
Questions
970
current versions
No studies
19.6%
Moderate or high
32.3%
No studies 190 · 19.6%Ungraded 42 · 4.3%Very low 135 · 13.9%Low 289 · 29.8%Moderate 242 · 24.9%High 72 · 7.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Thinnest evidence
All no studies and very low questions| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Immunomodulatory interventions vs placebo Seizure freedom · people with focal epilepsy Immunomodulatory interventions for focal epilepsy (2023) · Cochrane | no estimate extracted | NR | No studies |
Immunomodulatory interventions vs placebo Allergic reactions · people with focal epilepsy Immunomodulatory interventions for focal epilepsy (2023) · Cochrane | no estimate extracted | NR | No studies |
Immunomodulatory interventions vs placebo Cognitive effects · people with focal epilepsy Immunomodulatory interventions for focal epilepsy (2023) · Cochrane | no estimate extracted | NR | No studies |
Immunomodulatory interventions vs placebo Quality of life · people with focal epilepsy Immunomodulatory interventions for focal epilepsy (2023) · Cochrane | no estimate extracted | NR | No studies |
Rapid vs slow withdrawal of antiepileptic drugs Seizure freedom after 1 year of AED withdrawal · people with epilepsy Rapid versus slow withdrawal of antiepileptic drugs (2022) · Cochrane | RR 0.76 [0.58, 1.01] | 1 study · 149 participants | Very low |
Rapid vs slow withdrawal of antiepileptic drugs Seizure freedom after 2 years of AED withdrawal · people with epilepsy Rapid versus slow withdrawal of antiepileptic drugs (2022) · Cochrane | RR 0.87 [0.58, 1.29] | 1 study · 149 participants | Very low |
Rapid vs slow withdrawal of antiepileptic drugs Seizure freedom after 5 years of AED withdrawal · people with epilepsy Rapid versus slow withdrawal of antiepileptic drugs (2022) · Cochrane | RR 1.4 [0.54, 3.65] | 1 study · 149 participants | Very low |
Intervention NR Primary outcomes · patients with stroke Antiepileptic drugs for the primary and secondary prevention of seizures after stroke (2022) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Secondary seizure prophylaxis after stroke · patients with stroke Antiepileptic drugs for the primary and secondary prevention of seizures after stroke (2022) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Secondary outcomes · patients with stroke Antiepileptic drugs for the primary and secondary prevention of seizures after stroke (2022) · Cochrane | no estimate extracted | NR | No studies |
Pregabalin vs placebo Adverse effect: headache · drug‐resistant focal epilepsy Pregabalin add‐on for drug‐resistant focal epilepsy (2022) · Cochrane | RR 0.65 [0.45, 0.94] | 6 studies · 1850 participants | Very low |
Pregabalin vs active comparators 50% or greater reduction in seizure frequency ‐ best‐case analysis · drug‐resistant focal epilepsy Pregabalin add‐on for drug‐resistant focal epilepsy (2022) · Cochrane | RR 1.6 [1.17, 2.19] | 3 studies · 1286 participants | Very low |