Cochrane · systematic review · CD002217
Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures
Nolan Sarah J, Tudur Smith Catrin, Pulman Jennifer, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
EpilepsyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 25%Moderate 9 · 75%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: adults and children with newly diagnosed partial onset or generalised onset seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to treatment withdrawal ‐ all participants Range of | HR 1.62 [1.23, 2.14] | 3 studies · 499 participants | Low Downgraded: risk of bias, inconsistency |
Time to treatment withdrawal ‐ stratified by seizure type ‐ Generalised seizures Range of | HR 4.04 [1.61, 10.14] | 2 studies · 95 participants | Low Downgraded: risk of bias, inconsistency |
Time to treatment withdrawal ‐ stratified by seizure type ‐ Partial onset Range of | HR 1.48 [1.1, 1.98] | 3 studies · 404 participants | Low Downgraded: risk of bias, inconsistency |
Time to 12‐month remission ‐ all participants Range of | HR 0.9 [0.69, 1.19] | 4 studies · 599 participants | Moderate Downgraded: risk of bias, inconsistency |
Time to 12‐month remission ‐ stratified by seizure type ‐ Generalised seizures Range of | HR 0.77 [0.46, 1.28] | 3 studies · 131 participants | Moderate Downgraded: risk of bias, inconsistency |
Time to 12‐month remission ‐ stratified by seizure type ‐ Partial Onset Range of | HR 0.96 [0.7, 1.33] | 4 studies · 468 participants | Moderate Downgraded: risk of bias, inconsistency |
Time to 6‐month remission ‐ all participants Range of | HR 0.9 [0.71, 1.14] | 4 studies · 599 participants | Moderate Downgraded: risk of bias, inconsistency |
Time to 6‐month remission ‐ stratified by seizure type ‐ Generalised seizures Range of | HR 0.79 [0.51, 1.24] | 3 studies · 131 participants | Moderate Downgraded: risk of bias, inconsistency |
Time to 6‐month remission ‐ stratified by seizure type ‐ Partial onset Range of | HR 0.94 [0.71, 1.25] | 4 studies · 468 participants | Moderate Downgraded: risk of bias, inconsistency |
Time to first seizure ‐ all participants Range of | HR 0.86 [0.69, 1.08] | 4 studies · 592 participants | Moderate Downgraded: risk of bias, inconsistency |
Time to first seizure ‐ stratified by epilepsy type ‐ Generalised seizures Range of | HR 1.14 [0.73, 1.78] | 3 studies · 131 participants | Moderate Downgraded: risk of bias, inconsistency |
Time to first seizure ‐ stratified by epilepsy type ‐ Partial onset Range of | HR 0.78 [0.61, 1.01] | 4 studies · 461 participants | Moderate Downgraded: risk of bias, inconsistency |