Non-Cochrane · aetiology · PM41969404
Periodontal disease and obstructive sleep apnea: an umbrella review.
Coronel-Zubiate Franz Tito, Farje-Gallardo Carlos Alberto, Herrera-Plasencia Paul Martín, et al. · Frontiers in oral health · 2026 · PubMed · doi:10.3389/froh.2026.1780859
Findings
19 findings
| Population | ||||
|---|---|---|---|---|
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Probing depth Source meta-analysis: Zhu 2023; Periodontal clinical parameter | SMD 0.68 [0.06, 1.30] GRADE not reported Studies not reported |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Bleeding on probing Source meta-analysis: Zhu 2023; Periodontal clinical parameter | SMD 0.36 [0.08, 0.64] GRADE not reported Studies not reported |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Al-Jewair 2020; Adjusted model | OR 1.66 [1.28, 2.17] GRADE not reported 9 studies |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Al-Jewair 2015; Adjusted model | OR 1.65 [1.11, 2.46] GRADE not reported 4 studies |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Clinical attachment loss Source meta-analysis: Zhu 2023; Periodontal clinical parameter | SMD 0.69 [0.17, 1.22] GRADE not reported Studies not reported |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Liu 2023; Unadjusted general association (polysomnography-confirmed SDB) | OR 1.83 [1.52, 2.20] GRADE not reported 10 studies |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Khodadadi 2022; Adjusted model, general association Unresolved: the two extractors disagree on this row. | OR 1.75 [1.65, 1.85] GRADE not reported 10 studies |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Portelli 2024; Unadjusted general association | OR 2.46 [1.73, 3.49] GRADE not reported 10 studies |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Mild to moderate periodontitis Source meta-analysis: Khodadadi 2022; Mild to moderate periodontitis | OR 2.51 [1.32, 4.78] GRADE not reported Studies not reported |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Zhang 2022; Unadjusted general association | OR 1.56 [1.06, 2.06] GRADE not reported 6 studies |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Zhu 2023; Unadjusted general association | OR 2.35 [2.22, 2.48] GRADE not reported 13 studies |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Plaque index Source meta-analysis: Zhu 2023; Periodontal clinical parameter | SMD 0.11 [-0.18, 0.39] GRADE not reported Studies not reported |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Gingival index Source meta-analysis: Zhu 2023; Periodontal clinical parameter | SMD 0.18 [-0.18, 0.53] GRADE not reported Studies not reported |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Liu 2023; Adjusted model, general association Unresolved: the two extractors disagree on this row. | OR 1.68 [1.47, 1.92] GRADE not reported 10 studies |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Khodadadi 2022; Unadjusted general association | OR 2.17 [1.66, 2.83] GRADE not reported 10 studies |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Severe periodontitis Source meta-analysis: Liu 2023; Adjusted model, severe periodontitis | OR 1.39 [1.20, 1.61] GRADE not reported Studies not reported |
| Adults with obstructive sleep apnea (or sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Molina 2023; Adjusted model | OR 1.65 [1.21, 2.25] GRADE not reported 6 studies |
| Asian adults with obstructive sleep apnea (sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Liu 2023; Asian populations | OR 2.10 [1.57, 2.80] GRADE not reported Studies not reported |
| Non-Asian adults with obstructive sleep apnea (sleep-disordered breathing) | Obstructive sleep apnea (exposure) | No obstructive sleep apnea | Periodontitis (any) Source meta-analysis: Liu 2023; Non-Asian populations | OR 1.51 [1.21, 1.88] GRADE not reported Studies not reported |
Included primary studies 11
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Khodadadi 2022 Is periodontitis associated with obstructive sleep apnea? A systematic review and meta-analysis. PMID:35419178 | 2022 | 2 other reviews | not stated | not extracted yet |
| Liu 2023 Association between sleep-disordered breathing and periodontitis: a meta-analysis. PMID:36565220 | 2023 | 2 other reviews | not stated | not extracted yet |
| Molina 2023 The association between respiratory diseases and periodontitis: A systematic review and meta‐analysis DOI:10.1111/jcpe.13767 | 2023 | 2 other reviews | not stated | not extracted yet |
| Al-Jewair 2015 Periodontitis and obstructive sleep apnea’s bidirectional relationship: a systematic review and meta-analysis DOI:10.1007/s11325-015-1160-8 | 2015 | 1 other review | not stated | not extracted yet |
| Bianchi 2024 Relationship between periodontal disease and obstructive sleep apnea in adults: A systematic review DOI:10.4103/drj.drj_568_22 | 2024 | 1 other review | not stated | not extracted yet |
| Lembo 2021 Obstructive Sleep Apnea and Periodontal Disease: A Systematic Review DOI:10.3390/medicina57060640 | 2021 | 1 other review | not stated | not extracted yet |
| Al-Jewair 2020 An Update on the Association Between Periodontitis and Obstructive Sleep Apnea DOI:10.1007/s40496-020-00271-5 | 2020 | this review only | not stated | not extracted yet |
| Portelli 2024 Correlations between Obstructive Sleep Apnea Syndrome and Periodontitis: A Systematic Review and Meta-Analysis DOI:10.3390/dj12080236 | 2024 | this review only | not stated | not extracted yet |
| Rocha Rodrigues 2023 Is There an Association With Periodontitis and Obstructive Sleep Apnea? A Systematic Review DOI:10.15331/jdsm.7278 | 2023 | this review only | not stated | not extracted yet |
| Zhang 2022 Incidence and risk of periodontitis in obstructive sleep apnea: A meta-analysis DOI:10.1371/journal.pone.0271738 | 2022 | this review only | not stated | not extracted yet |
| Zhu 2023 A meta-analysis on the association between obstructive sleep apnea and periodontitis DOI:10.1007/s11325-022-02668-1 | 2022 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Primary research on people with periodontal disease and obstructive sleep apnea | Adults with OSA or sleep-disordered breathing (11 systematic reviews, 113 primary studies) |
| Intervention | Obstructive sleep apnea (exposure) | Obstructive sleep apnea (11 reviews) |
| Comparison | No obstructive sleep apnea | No obstructive sleep apnea |
| Outcomes | Association between periodontal disease and OSA; progression and severity of periodontal disease; periodontal clinical parameters (probing depth, clinical attachment loss, bleeding on probing, plaque index, gingival index) | General association (11 reviews; 8 meta-analyzed, OR 1.56 to 2.46); severity (2 reviews); continent (1 review); periodontal clinical parameters (1 review) |
| Study designs | Systematic reviews with or without meta-analysis; narrative and rapid reviews, trials, observational studies, protocols excluded | Systematic reviews of case-control and cross-sectional studies (n=11; 8 with meta-analysis) |
| Timing | Not specified | Not specified |