Non-Cochrane · aetiology · PM41907862
Association between sleep and periodontal disease in adults-an umbrella review.
Rajeev Keerthana, Janakiram Chandrashekar, S Vijay Kumar · Frontiers in oral health · 2026 · PubMed · doi:10.3389/froh.2026.1761243
Findings
9 findings
| Population | ||||
|---|---|---|---|---|
| Adults (>=18 years) | Insufficient sleep duration (average <7 h, self-reported) | Adequate sleep duration | Occurrence of periodontal disease Source review: Wu 2022 (insufficient sleep duration) | OR 1.19 [1.16, 1.23] GRADE not reported 6 studies · 107777 participants |
| Adults (>=18 years) | Short sleep duration (self-reported) | Normal sleep duration | Occurrence of periodontal disease Source review: Zhou 2024a (short sleep duration) | OR 1.04 [0.83, 1.29] GRADE not reported 10 studies · 66516 participants |
| Adults (>=18 years) | Short sleep duration (self-reported) | Normal sleep duration | Occurrence of periodontal disease Source review: Feixiang Zhou 2021 (short sleep) | OR 1.06 [0.89, 1.25] GRADE not reported 7 studies · 40196 participants |
| Adults (>=18 years) | Long sleep duration (self-reported) | Normal sleep duration | Occurrence of periodontal disease Source review: Zhou 2024b (long sleep duration) | OR 1.12 [0.94, 1.33] GRADE not reported 8 studies · 64449 participants |
| Adults (>=18 years) | Obstructive sleep apnea | No obstructive sleep apnea | Occurrence of periodontal disease Source review: Al-Jewair 2015 | OR 1.65 [1.11, 2.46] GRADE not reported 4 studies · 29955 participants |
| Adults (>=18 years) | Obstructive sleep apnea | No obstructive sleep apnea | Occurrence of periodontal disease Source review: Khodadadi 2022 | OR 2.17 [1.66, 2.83] GRADE not reported 10 studies · 30994 participants |
| Adults (>=18 years) | Obstructive sleep apnea | No obstructive sleep apnea | Occurrence of periodontal disease Source review: Molina 2022 | OR 1.65 [1.21, 2.25] GRADE not reported 6 studies · 43342 participants |
| Adults (>=18 years) | Sleep-disordered breathing (polysomnography confirmed) | No sleep-disordered breathing | Occurrence of periodontal disease Source review: Liu 2022 | OR 1.83 [1.52, 2.20] GRADE not reported 10 studies · 43296 participants |
| Adults aged 18 years or older | Sleep disorders (obstructive sleep apnea and sleep-disordered breathing) | No sleep disorder | Periodontal disease Overall umbrella synthesis across included reviews | Relative (95% CI): Not estimable; certainty Low (extremely serious risk of bias; inconsistency, indirectness and imprecision not serious) Low Downgraded: risk of bias 8 studies |
Included primary studies 13
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Khodadadi 2022 Is periodontitis associated with obstructive sleep apnea? A systematic review and meta-analysis. PMID:35419178 | 2022 | 2 other reviews | Occurrence of periodontal disease | not extracted yet |
| Liu 2022 Association between sleep-disordered breathing and periodontitis: a meta-analysis. PMID:36565220 | 2023 | 2 other reviews | Occurrence of periodontal disease; PM41907862-P5-O1 | not extracted yet |
| Molina 2022 The association between respiratory diseases and periodontitis: A systematic review and meta‐analysis DOI:10.1111/jcpe.13767 | 2023 | 2 other reviews | Occurrence of periodontal disease | not extracted yet |
| Al-Jewair 2015 Periodontitis and obstructive sleep apnea’s bidirectional relationship: a systematic review and meta-analysis DOI:10.1007/s11325-015-1160-8 | 2015 | 1 other review | Occurrence of periodontal disease | not extracted yet |
| Bianchi 2024 (periodontal disease and OSA) Relationship between periodontal disease and obstructive sleep apnea in adults: A systematic review DOI:10.4103/drj.drj_568_22 | 2024 | 1 other review | not stated | not extracted yet |
| Lembo 2021 Obstructive Sleep Apnea and Periodontal Disease: A Systematic Review DOI:10.3390/medicina57060640 | 2021 | 1 other review | not stated | not extracted yet |
| Bianchi 2022 (oral microbiota) Oral microbiota in obstructive sleep apnea patients: a systematic review DOI:10.1007/s11325-022-02718-8 | 2022 | this review only | not stated | not extracted yet |
| Malaiappan 2019 Association between Sleep and Periodontitis-A Systematic Review DOI:10.5958/0974-360x.2019.00422.0 | 2019 | this review only | not stated | not extracted yet |
| Muniz 2021 Are periodontal diseases associated with sleep duration or sleep quality? A systematic review DOI:10.1016/j.archoralbio.2021.105184 | 2021 | this review only | not stated | not extracted yet |
| Schmidlin 2020 Association between periodontal disease and non-apnea sleep disorder: a systematic review DOI:10.1007/s00784-020-03475-2 | 2020 | this review only | not stated | not extracted yet |
| Wu 2022 Is insufficient sleep duration a risk indicator for periodontal disease? A systematic review DOI:10.1111/idh.12633 | 2022 | this review only | Occurrence of periodontal disease | not extracted yet |
| Zhou 2021 Association of short sleep with risk of periodontal disease: A meta‐analysis and Mendelian randomization study DOI:10.1111/jcpe.13483 | 2021 | this review only | Occurrence of periodontal disease | not extracted yet |
| Zhou 2024 Sleep Duration and Risk of Periodontitis—A Systematic Review and Meta-Analysis DOI:10.1016/j.identj.2024.02.016 | 2024 | this review only | Occurrence of periodontal disease | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults aged 18 years or older, no restriction by sex, ethnicity, socioeconomic status, geography or general health | Adults in 13 included systematic reviews (52 unique primary studies) |
| Intervention | Sleep or sleep-related conditions (sleep duration, sleep disorders including obstructive sleep apnea) assessed by PSQI, ESS, SSS, Berlin, STOP/STOP-BANG, ARES, sleep diaries or physiological measures | Insufficient, short and long sleep duration; obstructive sleep apnea; sleep-disordered breathing; non-apnea sleep disorders |
| Comparison | Not specified | Not specified |
| Outcomes | Periodontal disease (CAL, PPD, ABL, gingival recession, plaque and gingival indices) | Periodontal disease or periodontitis (CAL, PPD, CPI and AHI-based or questionnaire exposure measures; oral microbiota in one review) |
| Study designs | Systematic reviews with or without meta-analysis | 13 systematic reviews (7 with meta-analysis, 6 narrative synthesis) of cross-sectional, case-control and cohort studies |
| Timing | Inception to present (searches March 2024) | Reviews published 2015 to 2024 |