Non-Cochrane · aetiology · PM42035465
Association Between Obstructive Sleep Apnea and Periodontitis: A Systematic Umbrella Review.
Mahmood Mohammed Khalid, Omer Shahen Hiwa, Gul Sarhang Sarwat, et al. · Clinical and experimental dental research · 2026 · PubMed · doi:10.1002/cre2.70300
Findings
8 findings
| Population | ||||
|---|---|---|---|---|
| Adults with obstructive sleep apnea (OSA) | Obstructive sleep apnea (exposure) | Participants without OSA (healthy periodontium) | Periodontitis (association with OSA) Study quality: high (AMSTAR 2) | OR 1.78 [1.52, 2.09] GRADE not reported 2 studies |
| Adults with obstructive sleep apnea (OSA) | Obstructive sleep apnea (exposure) | Participants without OSA (healthy periodontium) | Periodontitis (association with OSA) Sample size: under 40,000 | OR 2.21 [1.90, 2.57] GRADE not reported 3 studies |
| Adults with obstructive sleep apnea (OSA) | Obstructive sleep apnea (exposure) | Participants without OSA (healthy periodontium) | Periodontitis (association with OSA) Trim-and-fill adjusted | OR 2.24 [1.92, 2.60] GRADE not reported 7 studies |
| Adults with obstructive sleep apnea (OSA) | Obstructive sleep apnea (exposure) | Participants without OSA (healthy periodontium) | Periodontitis (association with OSA) | OR 1.96 [1.68, 2.29] Low Downgraded: inconsistency, publication bias 7 studies |
| Adults with obstructive sleep apnea (OSA) | Obstructive sleep apnea (exposure) | Participants without OSA (healthy periodontium) | Periodontitis (association with OSA) Study quality: moderate (AMSTAR 2) | OR 2.06 [1.72, 2.47] GRADE not reported 5 studies |
| Adults with obstructive sleep apnea (OSA) | Obstructive sleep apnea (exposure) | Participants without OSA (healthy periodontium) | Periodontitis (association with OSA) Sample size: over 40,000 | OR 1.81 [1.52, 2.16] GRADE not reported 4 studies |
| Adults with mild to moderate OSA | Mild to moderate OSA | Participants without OSA (healthy periodontium) | Periodontitis (association with OSA) OSA severity: mild-moderate | OR 1.82 [1.36, 2.43] GRADE not reported 2 studies |
| Adults with severe OSA | Severe OSA | Participants without OSA (healthy periodontium) | Periodontitis (association with OSA) OSA severity: severe | OR 2.25 [1.40, 3.61] GRADE not reported 2 studies |
Included primary studies 7
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Khodadadi 2022 Is periodontitis associated with obstructive sleep apnea? A systematic review and meta-analysis. PMID:35419178 | 2022 | 2 other reviews | Periodontitis (association with OSA) | not extracted yet |
| Liu 2022 Association between sleep-disordered breathing and periodontitis: a meta-analysis. PMID:36565220 | 2023 | 2 other reviews | Periodontitis (association with OSA) | not extracted yet |
| Al-Jewair 2015 Periodontitis and obstructive sleep apnea's bidirectional relationship: a systematic review and meta-analysis. PMID:25801281 | 2015 | this review only | Periodontitis (association with OSA) | not extracted yet |
| Molina 2023 The association between respiratory diseases and periodontitis: A systematic review and meta-analysis. PMID:36606394 | 2023 | this review only | Periodontitis (association with OSA) | not extracted yet |
| Portelli 2024 Correlations between Obstructive Sleep Apnea Syndrome and Periodontitis: A Systematic Review and Meta-Analysis. PMID:39195080 | 2024 | this review only | Periodontitis (association with OSA) | not extracted yet |
| Zhang 2022 Incidence and risk of periodontitis in obstructive sleep apnea: A meta-analysis. PMID:35862412 | 2022 | this review only | Periodontitis (association with OSA) | not extracted yet |
| Zhu 2023 A meta-analysis on the association between obstructive sleep apnea and periodontitis. PMID:35759182 | 2023 | this review only | Periodontitis (association with OSA) | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
| Review | Shared studies | Jaccard |
|---|---|---|
| Association between sleep and periodontal disease in adults-an umbrella review. (2026) | 2 | 0.11 |
| Periodontal disease and obstructive sleep apnea: an umbrella review. (2026) | 2 | 0.13 |
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adult patients with OSA and periodontitis | Adults >=18 years with OSA (7 meta-analyses, 23 unique primary studies, >225,000 participants) |
| Intervention | OSA (exposure) | OSA (PSG/AHI or questionnaires) |
| Comparison | Participants with healthy periodontium and without OSA | No OSA |
| Outcomes | Association (OR) between OSA and periodontitis | Periodontitis (pooled OR, n=7) |
| Study designs | Systematic reviews and meta-analyses reporting pooled ORs, English language | Meta-analyses of observational studies (n=7) |
| Timing | Published before December 2025 | Meta-analyses published 2015 to 2024 |