Non-Cochrane · umbrella · PM41969407
Association between periodontal disease and chronic obstructive pulmonary disease: an umbrella review.
Cruzado-Oliva Fredy Hugo, Reyes-Narváez Silvia Elizabet, Aguilar-Urbina Edi William, et al. · Frontiers in oral health · 2026 · PubMed · doi:10.3389/froh.2026.1728405
Findings
37 findings
| Population | ||||
|---|---|---|---|---|
| Adults with or without COPD | Periodontal disease (gingivitis and periodontitis) | Periodontal health (absence of periodontal disease) | COPD (presence or diagnosis) Included SR: Yang 2023; smokers | OR 1.46 [0.92, 2.31] GRADE not reported Studies not reported |
| Adults with or without COPD | Periodontal disease (gingivitis and periodontitis) | Periodontal health (absence of periodontal disease) | COPD (presence or diagnosis) Included SR: Zeng 2012 | OR 2.08 [1.48, 2.91] GRADE not reported 14 studies |
| Adults with or without COPD | Periodontal disease (gingivitis and periodontitis) | Periodontal health (absence of periodontal disease) | COPD (presence or diagnosis) Included SR: Gomes-Filho 2020 | OR 1.78 [1.04, 3.05] GRADE not reported 4 studies |
| Adults with or without COPD | Periodontal disease (gingivitis and periodontitis) | Periodontal health (absence of periodontal disease) | COPD (presence or diagnosis) Included SR: Molina 2023 | OR 1.28 [1.16, 1.42] Moderate 12 studies |
| Adults with or without COPD | Periodontal disease (gingivitis and periodontitis) | Periodontal health (absence of periodontal disease) | COPD (presence or diagnosis) Included SR: Yang 2023; smoking intensity (COPD intensity) | OR 1.14 [0.86, 1.51] GRADE not reported Studies not reported |
| Adults with or without COPD | Periodontal disease (gingivitis and periodontitis) | Periodontal health (absence of periodontal disease) | COPD exacerbations Included SR: Yang 2023 | OR 1.18 [0.71, 1.21] GRADE not reported Studies not reported |
| Adults with or without COPD | Periodontal disease (gingivitis and periodontitis) | Periodontal health (absence of periodontal disease) | COPD (presence or diagnosis) Included SR: Yang 2023; non-smokers | OR 0.93 [0.72, 1.21] GRADE not reported Studies not reported |
| Adults with or without COPD | Periodontal disease (gingivitis and periodontitis) | Periodontal health (absence of periodontal disease) | COPD (presence or diagnosis) Included SR: Yang 2023 | OR 1.2 [1.09, 1.32] GRADE not reported 18 studies |
| Adults with or without COPD | Periodontal disease (gingivitis and periodontitis) | Periodontal health (absence of periodontal disease) | COPD (presence or diagnosis) Included SR: Wu 2022 | OR 1.64 [1.19, 2.27] GRADE not reported 20 studies |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Clinical attachment level Included SR: Shi 2018 | MD 0.48 [0.28, 0.68] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Number of remaining teeth Included SR: Shi 2018 | MD -3.73 [-5.12, -2.33] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Alveolar bone loss Included SR: Wu 2022 | WMD 0.63 [0.26, 0.99] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Gingival index Included SR: Wu 2022 | WMD 0.41 [0.12, 0.7] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Clinical attachment level Included SR: Tan 2016; ex-smokers | OR 1.39 [0.77, 2.5] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Clinical attachment level Included SR: Tan 2016; smokers | OR 0.99 [0.98, 1.0] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Plaque index Included SR: Wu 2022 | WMD 0.29 [0.11, 0.47] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Plaque index Included SR: Tan 2016; non-smokers | OR 1.52 [0.76, 3.05] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Alveolar bone loss Included SR: Shi 2018 | MD 0.13 [0.0, 0.25] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Probing depth Included SR: Tan 2016; smokers | OR 0.43 [0.14, 1.31] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Bleeding index Included SR: Tan 2016; ex-smokers | OR 0.37 [0.13, 1.01] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Gingival index Included SR: Shi 2018 | MD 0.36 [0.04, 0.69] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Bleeding on probing Included SR: Shi 2018 | MD 6.88 [5.49, 8.27] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Clinical attachment level Included SR: Tan 2016; non-smokers Unresolved: the two extractors disagree on this row. | OR 1.0 [0.99, 1.01] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Bleeding index Included SR: Shi 2018 | MD 0.24 [-0.11, 0.59] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Probing depth Included SR: Wu 2022 | WMD 0.33 [0.11, 0.55] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Number of remaining teeth Included SR: Wu 2022 | WMD -3.51 [-4.66, -2.35] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Plaque index Included SR: Tan 2016; ex-smokers | OR 2.18 [0.89, 5.33] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Plaque index Included SR: Shi 2018 | MD 0.23 [0.04, 0.41] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Bleeding index Included SR: Tan 2016; non-smokers | OR 1.19 [0.58, 2.46] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Probing depth Included SR: Tan 2016; non-smokers | OR 0.3 [0.15, 0.62] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Clinical attachment level Included SR: Wu 2022 | WMD 0.69 [0.45, 0.93] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Plaque index Included SR: Tan 2016; smokers | OR 3.99 [2.58, 6.16] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Bleeding index Included SR: Tan 2016; smokers | OR 1.35 [0.57, 3.24] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Oral hygiene index Included SR: Shi 2018 | MD 0.8 [0.33, 1.28] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Alveolar bone loss Included SR: Yang 2023 | OR 1.98 [1.32, 2.97] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Oral hygiene index Included SR: Wu 2022 | WMD 0.81 [0.48, 1.14] GRADE not reported Studies not reported |
| Adults with COPD and adults without COPD | COPD | Adults without COPD | Probing depth Included SR: Shi 2018 | MD 0.26 [0.02, 0.5] GRADE not reported Studies not reported |
Included primary studies 38
Open in Studies| Study | Year | Also included by | Outcomes it informs here | Trial data |
|---|---|---|---|---|
| Molina 2023 The association between respiratory diseases and periodontitis: A systematic review and meta‐analysis DOI:10.1111/jcpe.13767 | 2023 | 2 other reviews | COPD (presence or diagnosis) | not extracted yet |
| Prasanna 2011 Causal relationship between periodontitis and chronic obstructive pulmonary disease. PMID:22368360 | 2011 | 1 other review | not stated | not extracted yet |
| AbdelHalim 2018 Chronic obstructive pulmonary disease exacerbations and periodontitis: a possible association DOI:10.4103/ejb.ejb_12_18 | 2018 | this review only | not stated | not extracted yet |
| Azarpazhooh 2006 Systematic Review of the Association Between Respiratory Diseases and Oral Health DOI:10.1902/jop.2006.060010 | 2006 | this review only | not stated | not extracted yet |
| Baldomero 2019 <p>The relationship between oral health and COPD exacerbations</p> DOI:10.2147/copd.s194991 | 2019 | this review only | not stated | not extracted yet |
| Barros 2013 A Cohort Study of the Impact of Tooth Loss and Periodontal Disease on Respiratory Events among COPD Subjects: Modulatory Role of Systemic… DOI:10.1371/journal.pone.0068592 | 2013 | this review only | not stated | not extracted yet |
| Bhavsar 2015 Periodontal status and oral health behavior in hospitalized patients with chronic obstructive pulmonary disease. PMID:26604629 | 2015 | this review only | not stated | not extracted yet |
| Chung 2016 Associations Between Periodontitis and Chronic Obstructive Pulmonary Disease: The 2010 to 2012 Korean National Health and Nutrition… DOI:10.1902/jop.2016.150682 | 2016 | this review only | not stated | not extracted yet |
| Deo 2009 Periodontitis as a potential risk factor for chronic obstructive pulmonary disease: A retrospective study DOI:10.4103/0970-9290.59456 | 2009 | this review only | not stated | not extracted yet |
| Garcia 2001 DOI:10.1902/anales.2001.6.1.71 | NR | this review only | not stated | not extracted yet |
| Gomes-Filho 2020 Periodontitis and respiratory diseases: A systematic review with meta‐analysis DOI:10.1111/odi.13228 | 2019 | this review only | COPD (presence or diagnosis) | not extracted yet |
| Harland 2018 Periodontitis modifies the association between smoking and chronic obstructive pulmonary disease in Japanese men DOI:10.2334/josnusd.17-0225 | 2018 | this review only | not stated | not extracted yet |
| Hayes 1998 DOI:10.1902/anales.1998.3.1.257 | NR | this review only | not stated | not extracted yet |
| Hyman 2004 Cigarette Smoking, Periodontal Disease, and Chronic Obstructive Pulmonary Disease DOI:10.1902/jop.2004.75.1.9 | 2004 | this review only | not stated | not extracted yet |
| Jung 2020 Association between oral health status and chronic obstructive pulmonary disease in Korean adults DOI:10.1111/idj.12535 | 2020 | this review only | not stated | not extracted yet |
| Kelly 2021 Periodontal status and chronic obstructive pulmonary disease (COPD) exacerbations: a systematic review DOI:10.1186/s12903-021-01757-z | 2021 | this review only | not stated | not extracted yet |
| Ledić 2013 matched by author and year (probable) | NR | this review only | not stated | not extracted yet |
| Leuckfeld 2008 Severe chronic obstructive pulmonary disease: Association with marginal bone loss in periodontitis DOI:10.1016/j.rmed.2007.12.001 | 2008 | this review only | not stated | not extracted yet |
| Liu 2012 Oral hygiene, periodontal health and chronic obstructive pulmonary disease exacerbations DOI:10.1111/j.1600-051x.2011.01808.x | 2011 | this review only | not stated | not extracted yet |
| Mushtaq 2019 DOI:10.5281/zenodo.3229308 | NR | this review only | not stated | not extracted yet |
| Öztekin 2014 The Association between Periodontal Disease and Chronic Obstructive Pulmonary Disease: A Case Control Study DOI:10.3109/15412555.2013.858316 | 2013 | this review only | not stated | not extracted yet |
| Peter 2013 Association Between Periodontal Disease and Chronic Obstructive Pulmonary Disease: A Reality or Just a Dogma? DOI:10.1902/jop.2013.120347 | 2013 | this review only | not stated | not extracted yet |
| Russell 1999 Respiratory pathogen colonization of the dental plaque of institutionalized elders DOI:10.1111/j.1754-4505.1999.tb01413.x | 1999 | this review only | not stated | not extracted yet |
| Scannapieco 1998 DOI:10.1902/anales.1998.3.1.251 | NR | this review only | not stated | not extracted yet |
| Scannapieco 2001 Potential Associations Between Chronic Respiratory Disease and Periodontal Disease: Analysis of National Health and Nutrition Examination… DOI:10.1902/jop.2001.72.1.50 | 2001 | this review only | not stated | not extracted yet |
| Scannapieco 2003 DOI:10.1902/anales.2003.8.1.54 | NR | this review only | not stated | not extracted yet |
| Shi 2018 Patients with Chronic Obstructive Pulmonary Disease Suffer from Worse Periodontal Health—Evidence from a Meta-Analysis DOI:10.3389/fphys.2018.00033 | 2018 | this review only | Oral hygiene index; Number of remaining teeth; Alveolar bone loss; Probing depth; Clinical attachment level; Plaque index; Gingival index; Bleeding index; Bleeding on probing | not extracted yet |
| Takeuchi 2019 Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease DOI:10.1177/0022034519833630 | 2019 | this review only | not stated | not extracted yet |
| Tan 2019 Relationship among clinical periodontal, microbiologic parameters and lung function in participants with chronic obstructive pulmonary… DOI:10.1002/jper.17-0705 | 2018 | this review only | not stated | not extracted yet |
| Terashima 2017 The association between dental health and nutritional status in chronic obstructive pulmonary disease DOI:10.1177/1479972316643076 | 2016 | this review only | not stated | not extracted yet |
| Vadiraj 2013 Periodontal Pathogens and Respiratory Diseases— Evaluating Their Potential Association: A Clinical and Microbiological Study DOI:10.5005/jp-journals-10024-1373 | 2013 | this review only | not stated | not extracted yet |
| Wang 2009 Periodontal health, oral health behaviours, and chronic obstructive pulmonary disease DOI:10.1111/j.1600-051x.2009.01448.x | 2009 | this review only | not stated | not extracted yet |
| Winning 2020 Periodontitis and airflow limitation in older Swedish individuals DOI:10.1111/jcpe.13287 | 2020 | this review only | not stated | not extracted yet |
| Wu 2022 Pulmonary disease and periodontal health: a meta-analysis DOI:10.1007/s11325-022-02577-3 | 2022 | this review only | COPD (presence or diagnosis); Oral hygiene index; Number of remaining teeth; Alveolar bone loss; Probing depth; Clinical attachment level; Plaque index; Gingival index | not extracted yet |
| Yang 2023 Association between chronic obstructive pulmonary disease and periodontal disease: a systematic review and meta-analysis DOI:10.1136/bmjopen-2022-067432 | 2023 | this review only | COPD (presence or diagnosis); COPD exacerbations; PM41969407-P1-O3; Oral hygiene index | not extracted yet |
| Yıldırım 2013 Periodontal health and serum, saliva matrix metalloproteinases in patients with mild chronic obstructive pulmonary disease DOI:10.1111/jre.12004 | 2012 | this review only | not stated | not extracted yet |
| Zeng 2012 Periodontal Disease and Risk of Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Observational Studies DOI:10.1371/journal.pone.0046508 | 2012 | this review only | COPD (presence or diagnosis) | not extracted yet |
| Zhou 2012 Serum levels of 25‐hydroxyvitamin D, oral health and chronic obstructive pulmonary disease DOI:10.1111/j.1600-051x.2012.01852.x | 2012 | this review only | not stated | not extracted yet |
Overlap with other reviews
Reviews that include the same primary studies are not independent evidence. Shared counts match studies by PMID, DOI or NCT, and otherwise by author and year (a probable match). Only the non-Cochrane dental reviews have study lists, so overlap with Cochrane reviews is not counted yet.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Adults (18 years or older) with or without COPD | Adults, predominantly 40 years or older, with or without COPD (n=12 SRs) |
| Intervention | Periodontal disease (including gingivitis and periodontitis) | Periodontal disease defined by CDC/AAP criteria or by individual parameters (n=12 SRs) |
| Comparison | Periodontal health (absence of periodontal disease) | Periodontal health or non-COPD controls (n=12 SRs) |
| Outcomes | Presence, severity, or exacerbations of COPD; periodontal parameters | COPD diagnosis (n=9 SRs), COPD exacerbations (n=2 SRs), smoking (n=1 SR), periodontal indicators (n=4 SRs) |
| Study designs | Systematic reviews with or without meta-analysis, no date or language restriction | SRs with meta-analysis (n=8) and SRs without meta-analysis (n=4) |
| Timing | Not specified | Not specified |