evidencegaps
Search

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

2,745 questions · 4,389 findings · 203 reviews · Oral Health

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 39 · 0.9%GRADE not reported 3,844 · 87.6%Very low 198 · 4.5%Low 137 · 3.1%Moderate 134 · 3.1%High 37 · 0.8%

Dental caries vs Adolescents without dental caries

Negative oral-health impact on daily performance (OIDP or Child-OIDP) · Adolescents (10-19 years)

In the Child-OIDP subgroup, dental caries is associated with a worse oral-health impact: PR 1.66 (95% CI 1.19 to 2.31) from 6 studies (I2=96%); ungraded, and not statistically different from the OIDP subgroup (p=0.96).

5 findings from 1 review
  • Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis. 2025 All outcomes
    Cross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months · School-based (17/20 studies), plus household and secondary-data surveys; low-, middle- and high-income countries (Brazil, Thailand, Tanzania, Saudi Arabia, Sri Lanka, Zambia, Iran, Serbia, Nepal, India, South Africa, China) · Instrument subgroup: Child-OIDP
    PR 1.66 [1.19, 2.31]
    6 studies
    GRADE not reported
  • Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis. 2025 All outcomes
    Cross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months · School-based (17/20 studies), plus household and secondary-data surveys; low-, middle- and high-income countries (Brazil, Thailand, Tanzania, Saudi Arabia, Sri Lanka, Zambia, Iran, Serbia, Nepal, India, South Africa, China) · Instrument subgroup: OIDP (all 3 studies)
    PR 1.68 [0.89, 3.17]
    3 studies
    GRADE not reported
  • Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis. 2025 All outcomes
    Cross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months · School-based (17/20 studies), plus household and secondary-data surveys; low-, middle- and high-income countries (Brazil, Thailand, Tanzania, Saudi Arabia, Sri Lanka, Zambia, Iran, Serbia, Nepal, India, South Africa, China) · Instrument subgroup: OIDP, sensitivity analysis excluding Krisdapong et al.
    PR 1.21 [1.15, 1.28]
    2 studies
    GRADE not reported
Show 2 more findings
  • Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis. 2025 All outcomes
    Cross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months · School-based (17/20 studies), plus household and secondary-data surveys; low-, middle- and high-income countries (Brazil, Thailand, Tanzania, Saudi Arabia, Sri Lanka, Zambia, Iran, Serbia, Nepal, India, South Africa, China) · Overall (all meta-analyzed studies pooled; both instruments and both caries definitions)
    PR 1.52 [1.15, 2.01]
    9 studies
    GRADE not reported
  • Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis. 2025 All outcomes
    Cross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months · School-based (17/20 studies), plus household and secondary-data surveys; low-, middle- and high-income countries (Brazil, Thailand, Tanzania, Saudi Arabia, Sri Lanka, Zambia, Iran, Serbia, Nepal, India, South Africa, China) · Caries-definition subgroup: presence of dental caries
    PR 1.19 [0.77, 1.84]
    3 studies
    GRADE not reported

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No cavity liner or a different liner material

Restoration longevity · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis

Cavity liners may make little or no difference to restoration longevity (high success across groups; low certainty).

1 finding from 1 review

Low tooth brushing frequency (<2 times/day) vs High tooth brushing frequency (>=2 times/day)

Early childhood caries (ECC) · Healthy children under 6 years of age (6 months to 6 years); preschool children

After excluding an extreme outlier (Alhabdan 2018), the association between low brushing frequency and ECC remained statistically significant (pooled OR approximately 2.0, p=0.003; I2=87.5%); the exact estimate and its CI were not reported; ungraded.

2 findings from 1 review

Low edentulism prevalence vs Not applicable

Oral health-related quality of life · people aged 60 years and older living in the community

No statistically significant difference in OHRQoL was reported by edentulism prevalence.

1 finding from 1 review

Breastfeeding for more than 24 months vs Not breastfed at the same age or breastfed for a shorter duration

Early childhood caries (ECC) - incidence/risk · Children with exclusively primary dentition (age ≤71 months)

Breastfeeding beyond 24 months is associated with an increased risk (incidence) of early childhood caries versus not breastfeeding at the same age (RR 2.44, 95% CI 1.97 to 3.02; low certainty).

1 finding from 1 review

Intervention not reported

Composite: Preference for replacement over repair - Scenario 2: loss of dental hard substance adjacent to the restoration

The intervention showed no clear difference in composite: Preference for replacement over repair - Scenario 2: loss…; GRADE not reported.

1 finding from 1 review

Glass ionomer (modified glass ionomer varnish) vs Non-invasive measures (standard of care)

Radiographic proximal caries lesion progression · Children with non-cavitated proximal caries lesions in primary teeth (ages 5-8)

In one trial, glass ionomer varnish showed no statistically significant difference versus non-invasive care in radiographic proximal caries progression (OR 0.58, CI includes 1; ungraded subgroup).

1 finding from 1 review

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Lumbar spine and pelvis fracture · European GWAS participants

The SVMR Weighted Median interval included the null.

3 findings from 1 review

Electronic cigarette use vs Non-smokers

Interleukin-8 (IL-8) · Humans who use e-cigarettes (mostly adults, often with periodontal disease) assessed for oral proinflammatory markers

Meta-analysis suggests no significant effect of e-cigarette use on the salivary level of Interleukin-8 (IL-8) (6 studies), though heterogeneity was high (I2=84%) and the pooled estimate appears only in Figure 3C (unavailable); GCF data were limited (1 study(ies)) (ungraded).

1 finding from 1 review

Electronic cigarette use vs Non-smokers

DMFT/DMFS index (dental caries experience) · Humans who use e-cigarettes (adolescents to adults) assessed for dental caries

A meta-analysis of 3 studies compared DMFT/DMFS in e-cigarette users vs non-smokers, but the pooled effect appears only in Figure 3A (unavailable) and heterogeneity was very high (I2=98%); the effect of vaping on dental caries remains unclear (ungraded).

1 finding from 1 review

Lower unemployment rate vs Higher unemployment rate (low <=5% / medium >5-10% / high >10%)

Caries experience (mean DMFT) · 12-year-old children across European countries (national/regional epidemiological surveys, 2011-2022)

Mean DMFT tended to increase with unemployment rate (low 1.23, medium 2.08, high 2.38; ANOVA p<.05); descriptive country-level means only, not meta-analyzed or GRADE-rated.

3 findings from 1 review

Mesoporous silica (SiO2) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Silica vs Fluorine showed no significant difference in 24 h bond strength (MD 1.441, 95% CI -5.099 to 7.980; Moderate certainty).

1 finding from 1 review

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Osteoporosis · European GWAS participants

The SVMR MR-Egger interval included the null.

4 findings from 1 review
Show 1 more finding