retention and abstinence, all patients · patients with opioid dependence
naltrexone showed no clear difference in retention and abstinence, all patients compared with placebo or no pharmacological treatments; GRADE not reported.
1 finding from 1 review
Abstinence · patients with opioid dependence
naltrexone showed no clear difference in abstinence at compared with placebo or no pharmacological treatments; GRADE not reported.
1 finding from 1 review
Side effects · patients with opioid dependence
naltrexone showed no clear difference in side effects compared with placebo or no pharmacological treatments; GRADE not reported.
1 finding from 1 review
Criminal activity dichotomous ‐ Reincarceration official records · patients with drug‐using offenders
Summary of findings for the main comparisons: Antagonost (Naltrexone) probably leads to lower criminal activity dichotomous ‐ Reincarceration official records compared with no pharmacological (moderate certainty).
1 finding from 1 review
Drug use · patients with drug‐using offenders
Summary of findings for the main comparisons: Antagonost (Naltrexone) showed no clear difference in drug use (objective) urine screen compared with no pharmacological (low certainty).
1 finding from 1 review
Peak withdrawal severity ‐ Naltrexone · opioid dependent adults
1 finding from 1 review
Overall withdrawal severity ‐ Naltrexone · opioid dependent adults
1 finding from 1 review
Completion rate ‐ Naltrexone · opioid dependent adults
1 finding from 1 review
Initiation of naltrexone treatment Number of participants initiating naltrexone · patients with opiate dependent adolescents
Buprenorphine probably leads to higher initiation of naltrexone treatment Number of participants initiating… compared with clonidine (moderate certainty).
1 finding from 1 review
Intervention not reported
Number commencing naltrexone maintenance treatment ‐ Clonidine comparison · patients with opioid withdrawal
The intervention probably leads to higher number commencing naltrexone maintenance treatment ‐ Clonidine… (moderate certainty).
1 finding from 1 review
Intervention not reported
Number commencing naltrexone maintenance treatment ‐ Buprenorphine comparison · patients with opioid withdrawal
The intervention probably leads to higher number commencing naltrexone maintenance treatment ‐ Buprenorphine… (moderate certainty).
1 finding from 1 review
Intervention not reported
Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Tapered methadone comparison · patients with opioid withdrawal
The intervention showed no clear difference in retained in naltrexone maintenance treatment or abstinent at 12… (low certainty).
1 finding from 1 review
Intervention not reported
Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Clonidine comparison · patients with opioid withdrawal
The intervention probably leads to higher retained in naltrexone maintenance treatment or abstinent at 12… (moderate certainty).
1 finding from 1 review
Intervention not reported
Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Buprenorphine comparison · patients with opioid withdrawal
The intervention showed no clear difference in retained in naltrexone maintenance treatment or abstinent at 12… (moderate certainty).
1 finding from 1 review
Continuous abstinence from cocaine (number of participants who had achieved and maintained abstinence for at least three weeks at the end of treatment) · patients with the treatment of cocaine dependence
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Point abstinence (number of participants who were abstinent at the end of the treatment) · patients with the treatment of cocaine dependence
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ total dropouts · patients with the treatment of cocaine dependence
It is very uncertain whether summary of findings table – disulfiram changes dropout for any reason (number of participants who did not complete… compared with naltrexone (very low certainty).
1 finding from 1 review
Dropouts due to adverse events · patients with the treatment of cocaine dependence
It is very uncertain whether summary of findings table – disulfiram changes dropout due to adverse events (number of participants who did not… compared with naltrexone (very low certainty).
1 finding from 1 review
RR 0.5 [0.07, 3.55]
1 study · 8 participants
Very low
Adverse events as N of participants with at least one adverse event objective · patients with the treatment of cocaine dependence
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Frequency of cocaine use (mean number of days or weeks of cocaine use at the end of treatment) · patients with the treatment of cocaine dependence
1 finding from 1 review