Cochrane · systematic review · CD002021
Opioid antagonists with minimal sedation for opioid withdrawal
Gowing, L, Ali, R, White, JM · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 6 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antagonist‐adrenergic combination compared to adrenergic agonist for opioid withdrawal
Population: opioid dependent adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Peak withdrawal severity ‐ Naltrexone Antagonist‐adrenergic combination vs adrenergic agonist | no estimate extracted | 2 studies · 184 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Peak withdrawal severity ‐ Naloxone Antagonist‐adrenergic combination vs adrenergic agonist | no estimate extracted | 1 study · 91 participants | Very low Downgraded: risk of bias, imprecision |
Overall withdrawal severity ‐ Naltrexone Antagonist‐adrenergic combination vs adrenergic agonist | no estimate extracted | 3 studies · 256 participants | Very low Downgraded: imprecision, inconsistency |
Overall withdrawal severity ‐ Naloxone Antagonist‐adrenergic combination vs adrenergic agonist | no estimate extracted | 1 study · 49 participants | Very low Downgraded: risk of bias, imprecision |
Completion rate ‐ Naltrexone Antagonist‐adrenergic combination vs adrenergic agonist | no estimate extracted | 4 studies · 330 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Completion rate ‐ Naloxone Antagonist‐adrenergic combination vs adrenergic agonist | no estimate extracted | 6 studies · 463 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |