Cochrane · systematic review · CD006749
Detoxification treatments for opiate dependent adolescents
Minozzi, S, Amato, L, Bellisario, C, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Drugs and AlcoholAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Buprenorphine versus clonidine for opiate dependent adolescents
Population: patients with opiate dependent adolescents
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Drop out Number of participants who did not complete the detoxification treatment Buprenorphine vs clonidine | RR 0.45 [0.2, 1.04] | 1 study · 36 participants | Moderate Downgraded: imprecision |
Duration and severity of signs and symptoms of withdrawal Adjective rating scale Buprenorphine vs clonidine | no estimate extracted | 1 study · 32 participants | Moderate Downgraded: imprecision |
Initiation of naltrexone treatment Number of participants initiating naltrexone Buprenorphine vs clonidine | RR 11 [1.58, 76.55] | 1 study · 36 participants | Moderate Downgraded: imprecision |
Buprenorphine detox compared with buprenorphine maintenance for opiate dependent adolescents
Population: patients with opiate dependent adolescents
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Drop out Number of participants who dropped out from the study Buprenorphine detox vs buprenorphine maintenance | RR 2.67 [1.85, 3.86] | 1 study · 152 participants | Low Downgraded: risk of bias, imprecision |
Patients with positive urine at the end of treatment Number of participants with urine positive for opiates Buprenorphine detox vs buprenorphine maintenance | RR 1.03 [0.82, 1.28] | 1 study · 152 participants | Low Downgraded: risk of bias, imprecision |
Self‐reported use at 12 months Buprenorphine detox vs buprenorphine maintenance | RR 1.36 [1.05, 1.76] | 1 study · 152 participants | Low Downgraded: risk of bias, imprecision |
Enrolment in addiction treatment at 12 month Buprenorphine detox vs buprenorphine maintenance | RR 0.75 [0.53, 1.07] | 1 study · 152 participants | Low Downgraded: risk of bias, imprecision |