Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

973 questions · 1,024 findings · 106 reviews

No studies found 235 · 22.9%GRADE not reported 59 · 5.8%Very low 207 · 20.2%Low 271 · 26.5%Moderate 177 · 17.3%High 75 · 7.3%

Vitamin D vs placebo or no intervention

Cancer occurrence in trials using vitamin D₃ (cholecalciferol) · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D showed no clear difference in cancer occurrence in trials using vitamin D₃ (cholecalciferol) compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Cancer mortality in trials using vitamin D3 (cholecalciferol) ( · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D may leads to lower cancer mortality in trials using vitamin D₃(cholecalciferol) compared with placebo or no intervention (low certainty).

1 finding from 1 review

Vitamin D vs placebo or no intervention

Adverse events ‐ Nephrolithiasis in trials using vitamin D3 combined with calcium · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D may leads to higher adverse events: nephrolithiasis in trials using vitamin… compared with placebo or no intervention (low certainty).

1 finding from 1 review

Vitamin D given to infants vs vitamin D given to lactating mothers

Vitamin D insufficiency: 25‐OH vitamin D < 50 nmol/L · term breastfed infants to prevent vitamin D deficiency and improve bone health

It is very uncertain whether vitamin D given to infants changes vitamin D insufficiency: 25‐OH vitamin D < 50 nmol/L compared with vitamin D given to lactating mothers (very low certainty).

1 finding from 1 review

Vitamin D given to infants vs vitamin D given to lactating mothers

Vitamin D deficiency: 25‐OH vitamin D < 30 nmol/L · term breastfed infants to prevent vitamin D deficiency and improve bone health

It is very uncertain whether vitamin D given to infants changes vitamin D deficiency: 25‐OH vitamin D < 30 nmol/L compared with vitamin D given to lactating mothers (very low certainty).

1 finding from 1 review

Vitamin D3 vs placebo

Cognitive function · cognitively healthy people in mid and late life
2 findings from 1 review

Vitamin D given to infants vs placebo or no treatment

Vitamin D insufficiency: 25‐OH vitamin D < 50 nmol/L · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to infants may leads to lower vitamin D insufficiency: 25‐OH vitamin D < 50 nmol/L compared with placebo or no treatment (low certainty).

1 finding from 1 review

Vitamin D given to infants vs placebo or no treatment

Vitamin D deficiency: 25‐OH vitamin D < 30 nmol/L · term breastfed infants to prevent vitamin D deficiency and improve bone health

It is very uncertain whether vitamin D given to infants changes vitamin D deficiency: 25‐OH vitamin D < 30 nmol/L compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Vitamin D given to lactating mothers vs placebo or no treatment

Vitamin D insufficiency: 25‐OH vitamin D < 50 nmol/L · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to lactating mothers may leads to lower vitamin D insufficiency: 25‐OH vitamin D < 50 nmol/L compared with placebo or no treatment (low certainty).

1 finding from 1 review

Vitamin D given to lactating mothers vs placebo or no treatment

Vitamin D deficiency: 25‐OH vitamin D < 30 nmol/L · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to lactating mothers may leads to lower vitamin D deficiency: 25‐OH vitamin D < 30 nmol/L compared with placebo or no treatment (low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Maternal vitamin B12 deficiency · pregnant women

It is very uncertain whether summary of findings table ‐ Vitamin B12 supplementation changes maternal vitamin B12 deficiency compared with placebo/no vitamin B12 supplementation (very low certainty).

1 finding from 1 review

High-dose vitamin D3 supplementation during pregnancy (2400 IU/day from pregnancy week 24 to 1 week postpartum, in addition to the recommended 400 IU/day) vs Low-dose (standard) vitamin D supplementation as recommended in national pregnancy guidelines

Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

It is very uncertain whether high-dose vitamin D3 supplementation during pregnancy (2400 IU/day… changes caries presence in primary teeth compared with low-dose (standard) vitamin D supplementation as recommended in… (very low certainty).

1 finding from 1 review

High-dose vitamin D3 supplementation during pregnancy (2400 IU/day from pregnancy week 24 to 1 week postpartum, in addition to the recommended 400 IU/day) vs Low-dose (standard) vitamin D supplementation as recommended in national pregnancy guidelines

Dental caries · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

The review found no eligible studies for this question.

2 findings from 1 review