Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

884 questions · 892 findings · 68 reviews · Anaesthesia

No studies found 118 · 13.2%GRADE not reported 156 · 17.5%Very low 187 · 21%Low 270 · 30.3%Moderate 119 · 13.3%High 42 · 4.7%

Beta‐blockers vs control—non‐cardiac surgery

Cerebrovascular events—non‐cardiac surgery · patients with conditions requiring non‐cardiac surgery

Beta‐blocker showed no clear difference in cerebrovascular events—non‐cardiac surgery compared with control—non‐cardiac surgery (low certainty).

1 finding from 1 review

Beta‐blockers vs control—non‐cardiac surgery

Ventricular arrhythmias—non‐cardiac surgery ECG · patients with conditions requiring non‐cardiac surgery

Beta‐blocker showed no clear difference in ventricular arrhythmias—non‐cardiac surgery ECG compared with control—non‐cardiac surgery (moderate certainty).

1 finding from 1 review

Beta‐blockers vs control—non‐cardiac surgery

All supraventricular arrhythmias—non‐cardiac surgery ECG · patients with conditions requiring non‐cardiac surgery

Beta‐blocker leads to lower all supraventricular arrhythmias—non‐cardiac surgery ECG compared with control—non‐cardiac surgery (high certainty).

1 finding from 1 review

Beta‐blockers vs control—non‐cardiac surgery

Bradycardia—non‐cardiac surgery ECG · patients with conditions requiring non‐cardiac surgery

Beta‐blocker probably leads to higher bradycardia—non‐cardiac surgery ECG compared with control—non‐cardiac surgery (moderate certainty).

1 finding from 1 review

Beta‐blockers vs control—non‐cardiac surgery

All‐cause mortality (30 days)—non‐cardiac surgery · patients with conditions requiring non‐cardiac surgery

Beta‐blocker showed no clear difference in all‐cause mortality (30 days)—non‐cardiac surgery compared with control—non‐cardiac surgery (low certainty).

1 finding from 1 review

Beta‐blockers vs control—non‐cardiac surgery

Acute myocardial infarction—non‐cardiac surgery · patients with conditions requiring non‐cardiac surgery

Beta‐blocker leads to lower acute myocardial infarction—non‐cardiac surgery compared with control—non‐cardiac surgery (high certainty).

1 finding from 1 review

Topical anaesthesia plus intracameral lidocaine vs topical anaesthesia alone

Need for additional anaesthesia during surgery Assessed dichotomously, as 'additional anaesthesia given' or 'additional anaesthesia not given' · adults undergoing phacoemulsification cataract surgery

Topical anaesthesia plus intracameral lidocaine showed no clear difference in need for additional anaesthesia during surgery Assessed… compared with topical anaesthesia alone (low certainty).

1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Subgroup Hb concentration immediately prior to surgery (g/dL) rHuEPO high (500 to 600 IU/kg BW) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia
1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Subgroup Hb concentration immediately prior to surgery (g/dL) rHuEPO low (150 to 300 IU/kg BW) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia
1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Mortality (within 30 days after surgery) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

rHuEPO with iron showed no clear difference in mortality (within 30 days after surgery) compared with control treatment with or without iron (moderate certainty).

1 finding from 1 review

Epidural analgesia vs peripheral nerve blocks

Pain at rest at 6 to 8 hours (score from 0 to 10) · adults undergoing cardiac surgery without cardiopulmonary bypass

It is very uncertain whether epidural analgesia changes pain at rest at 6 to 8hours after surgery (score from 0 to 10) compared with peripheral nerve blocks (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Surgery‐related complications (during longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Perioperative restrictive fluid therapy vs goal‐directed fluid therapy

Non‐surgery‐related complications (during longest · adults receiving intravenous fluids while undergoing major non‐cardiac surgery

It is very uncertain whether perioperative restrictive fluid therapy changes non‐surgery‐related complications (during longest compared with goal‐directed fluid therapy (very low certainty).

1 finding from 1 review

Epidural analgesia vs systemic analgesia

Vomiting · children having undergone thoraco‐lumbar spine surgery. 3 trials included in the analysis contained participants older than 18 years:…

Epidural analgesia showed no clear difference in vomiting up to 48 hours after surgery compared with systemic analgesia (low certainty).

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

Acute stroke (within 30‐days after surgery: new focal neurologic deficit with signs and symptoms lasting longer than 24 hours) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists may leads to lower acute stroke (within 30‐days after surgery: new focal neurologic… compared with control (low certainty).

1 finding from 1 review