Oral health-related quality of life · Children with dental caries
The direct estimate found no statistically significant difference in oral health-related quality of life between placebo and silver diamine fluoride.
2 findings from 1 review
Caries increment in permanent teeth · Children or adolescents
The NMR reported an SMD by randomisation year; no GRADE assessment was reported.
1 finding from 1 review
Caries increment, surface index D(M)FS · Children or adolescents
In the illustrative network meta-regression the SMD for caries increment differed between placebo and no treatment at randomization years 1970 to 1990; certainty was not graded.
1 finding from 1 review
Lactobacillus count (pre- vs post-treatment) · Medically healthy individuals (adults and children, 6-60 years)
Placebo rinse did not significantly change Lactobacillus counts relative to baseline; not GRADE-rated.
1 finding from 1 review
Plaque · Medically healthy individuals (adults and children, 6-60 years)
Placebo rinse did not significantly change plaque relative to baseline; not GRADE-rated.
1 finding from 1 review
Streptococcus mutans count · Medically healthy individuals (adults and children, 6-60 years)
Placebo rinse did not significantly change Streptococcus mutans counts relative to baseline; not GRADE-rated.
1 finding from 1 review
Coronal carious lesions prevention · Children with coronal carious lesions (primary dentition)
One review reported a 54% prevented fraction for fluoride varnish versus placebo for preventing coronal caries in primary teeth (one study; ungraded; comparator intervention, not SDF).
1 finding from 1 review
Prevented Fraction 54
1 study
GRADE not reported
Streptococcus mutans colonization reduction (narrative; no CFU data reported) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
Anticaries vaccines produced a sustained reduction in Streptococcus mutans colonization on teeth in animal models (ungraded narrative synthesis; no pooled estimate).
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 6 months, the Hall technique had significantly higher treatment success than placebo (OR 163.59; moderate certainty).
1 finding from 1 review
Incidence of initial caries around brackets, aesthetic-zone teeth only · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
When only aesthetic-zone teeth (incisors and canines) were considered, two studies reported a significant reduction in initial caries incidence favoring fluoride mouthrinse (ungraded, narrative; no pooled estimate).
1 finding from 1 review
Salivary / secretory IgA (SIgA) antibody response (immunogenicity) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
Anticaries vaccines, particularly via mucosal (intranasal) routes, elicited increased salivary/secretory IgA responses in the animal studies (ungraded narrative synthesis; no pooled estimate).
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Improved caries prognosis via restored oral microbiota · Patients after dental filling
Adjuvant postbiotics after dental filling improve caries prognosis by restoring the oral microbiota in one RCT (ungraded).
1 finding from 1 review
Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 6 months, ART had significantly higher treatment success than placebo (OR 16.18).
1 finding from 1 review
OR 16.18 [1.21, 215.73]
44 studies
GRADE not reported
Serum IgG antibody response (immunogenicity) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
Anticaries vaccines elicited increased serum IgG antibody responses across the animal studies (ungraded narrative synthesis; no pooled estimate).
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 6 months, conventional restorations had significantly higher treatment success than placebo (OR 44.66).
1 finding from 1 review
OR 44.66 [3.22, 620.47]
44 studies
Moderate
Incidence of proximal (interdental) caries lesions from bitewing radiographs · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Only one included study assessed proximal caries incidence from bitewing radiographs; it was not included in the meta-analysis and no pooled estimate is available (ungraded).
1 finding from 1 review
Reduced dental plaque index · Adults with dental caries
Postbiotic lozenges reduce plaque index in one adult RCT (ungraded).
1 finding from 1 review
Streptococcus mutans count · Humans at risk of dental caries (children aged 6-12 years; adults with dental caries)
Postbiotic products reduce salivary S. mutans counts in human trials, though not always significantly (ungraded narrative synthesis).
1 finding from 1 review
Development of >=1 new carious lesion (caries incidence) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system
In preclinical animal models, anticaries vaccines significantly reduced dental caries risk (pooled RR 0.53, 95% CI 0.46 to 0.62; random-effects), but the evidence is ungraded and limited to short-term animal studies.
1 finding from 1 review
RR 0.53 [0.46, 0.62]
Studies not reported
GRADE not reported
Treatment success (caries lesion arrest or restoration survival) · Children (aged 3-11 y) with cavitated caries lesions in primary teeth
At 6 months, SDF had significantly higher treatment success than placebo (OR 33.62).
1 finding from 1 review
OR 33.62 [3.01, 375.92]
44 studies
GRADE not reported