Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

25 questions · 30 findings · 6 reviews · Anaesthesia

No studies found 0 · 0%GRADE not reported 1 · 3.3%Very low 4 · 13.3%Low 18 · 60%Moderate 6 · 20%High 1 · 3.3%

Induction and maintenance: sevoflurane + nitrous oxide (N2O) vs propofol + N2O

Number of patients with postoperative nausea and vomiting (postoperative care unit) · paediatric

Induction and maintenance: sevoflurane + nitrous oxide (N2O) may leads to higher postoperative nausea and vomiting compared with propofol + N2O (low certainty).

1 finding from 1 review

Induction and maintenance: sevoflurane + nitrous oxide (N2O) vs propofol + N2O

Postoperative behavioural disturbances Different scales · paediatric

It is very uncertain whether induction and maintenance: sevoflurane + nitrous oxide (N2O) changes postoperative behavioural disturbances Different scales compared with propofol + N2O (very low certainty).

1 finding from 1 review

Induction and maintenance: sevoflurane + nitrous oxide (N2O) vs propofol + N2O

Intraoperative and postoperative respiratory and cardiovascular complications · paediatric

It is very uncertain whether induction and maintenance: sevoflurane + nitrous oxide (N2O) changes intraoperative and postoperative respiratory and cardiovascular… compared with propofol + N2O (very low certainty).

1 finding from 1 review

Maintenance anaesthesia: inhalational vs intravenous

Nausea and vomiting ‐ subgroup analysis: thiopentone or halothane + N2O versus propofol or propofol + N2O · paediatric

Maintenance anaesthesia: inhalational may leads to higher nausea and vomiting ‐ subgroup analysis: thiopentone or halothane +… compared with intravenous (low certainty).

2 findings from 1 review

Intervention not reported

Perioperative bleeding requiring non‐surgical intervention · patients with paediatric tonsillectomy

The intervention showed no clear difference in perioperative bleeding requiring non‐surgical intervention (moderate certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Mortality within the longest · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (at longest compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

All‐cause mortality (up to 30 days) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (up to 30 days) compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Blood loss requiring transfusion of blood products (intraoperatively and postoperatively) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in blood loss requiring transfusion of blood products (intraoperatively… compared with discontinuation of antiplatelet therapy (moderate certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Blood loss requiring further surgery (intraoperatively and postoperatively) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in blood loss requiring further surgery (intraoperatively and… compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Ischaemic events: peripheral thrombosis, cerebral myocardial infarction (within 30 days of surgery) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in ischaemic events: peripheral thrombosis, cerebral myocardial… compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults and paediatric patients with dermal laceration
5 findings from 1 review
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Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents

Anaesthetic‐related adverse effects · adults and paediatric patients with dermal laceration

Primary outcome: topical local anaesthetics led to lower anaesthetic‐related adverse effects compared with infiltrated local anaesthetics or other topical agents; GRADE not reported.

1 finding from 1 review

Intervention not reported

Mortality within the longest · surgical patients with need for abdominal, caesarean section, orthopaedic or breast surgery

The intervention showed no clear difference in mortality within the longest (low certainty).

1 finding from 1 review

Intervention not reported

Mortality within the longest · surgical patients with need for abdominal, caesarean section, orthopaedic or breast surgery

It is very uncertain whether the intervention changes mortality within the longest (very low certainty).

1 finding from 1 review